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Prostate cancer > combined androgen blockade - CAB > Flashcards

combined androgen blockade - CAB Flashcards

1
Q

what are 2 mechnisms of androgen reactivation

A
  1. tumour heterogeneously composed cells hormone dependent + independent
  2. stimulated by extratesticular androgen + intratumoral synthesis converted intracellularly –> DHT
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2
Q

What interfers with androgen reactivation?

A

CAB (LHRH agonsit/ orchiectomy + 1st generation antigens)

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3
Q

Use of CAB

A
  • initial therpay metastic PCa
  • LHRH monotherapy / CAB
  • intermittent ADT dosing stratgeis - restor QOL = considered a/e
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Prostate cancer (16 decks)

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