Aetiology

Question 1

Is Age the greatest predictor risk of PCa ?

Answer 1

< 40 - disease rare

incidence increase sharply as age increases

Question 2

Does family history contribute to PCa?

Answer 2

• family who has PCa = twice risk
• inherited
• potential PCa candidate genes + familiar clustering
• carriers germline mutations to one of 16 DNA repair genes: BRAC1/2 CHECK2 - increased risk PCa
• exposure environmental / other RF increase PCa
  (germline testing required for metastatic, regional high-very high risk localised PC

Question 3

does BPH increase risk of PCa?

Answer 3

No it doesnt

Question 4

Is smoking a RF?

Answer 4

No but smokers with PCa have increased mortality with PCa