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Prostate cancer > Early stage disease antiandrogens - AMIDE > Flashcards

Early stage disease antiandrogens - AMIDE Flashcards

1
Q

MOA

A
  • bind cytosolic AR

- deccrease available binding sites for endogenous androgens

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2
Q

1st generation androgens

A
  1. flutamide

2. bicalutamide

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3
Q

use of antiandrogens

A
  • monotherapy + 1st gen antiandrogens < effective than LHRH agonists
  • advanced PCa
  • antiandrogens ONLY in combo with ADT (LHRH agonists )
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Prostate cancer (16 decks)

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