Early stage disease GnRH antagonists IX

Question 1

MOA degarelix

Answer 1

• reversibly bind GnRH-R on pituary gland

- decrease testosterone to castration levels

Question 2

Advantage degarelix

Answer 2

• castration levels reached in 7 days /<

- elminate risk tumour flare + need for antiandrogen

Question 3

Avaialbility + dosage adm degarelix

Answer 3

• degarelix equivalent leuprolide
• advanced PCa
• 80mg / 120mg vials - SC
• starting dose 240mg followed 80mg per month
• starting dose split in 2 120mg injections

Question 4

Adverse effects degeralix

Answer 4

• inj site rxns
• LFT elevations
• osteoperosis
  ADVICE CA + VIT D supp