Castration-resistance prostate cancer - CRPC

Question 1

What happens in advance stages of PCa?

Answer 1

• PCa cells survive + proliferate without growth signals

- provided circulating androgens

Question 2

What is CRPC?

Answer 2

• hormone-refractory / androgn-indepedent PCa
• PCa cells survive + proliferate without growth signals from circulating androgens
• reintroduction androgens = continue promote tumour growth
• tumour responsive to secondary hormonal manuiplations