Metabolic Diseases and Trace Elements of Cattle Flashcards
What is milk fever?
Hypocalcaemia +/- hypophosphataemia
How does PTH control calcium levels?
What does calcitonin do?
What does Vitamin D3 do?
PTH: Increases calcium absorption from the gut
Mobilises calcium from bone
Calcitonin: reduces calcium absorption
Vitamin D3: Increases calcium absorption from the gut
What are 4 differential diganosis for a recumbent cow after calving?
- Milk fever
- Acute coliform mastitis
- Botulism
- Calving injury (nerve damage, femoral head fracture/dislocation)
What is the treatment for milk fever?
What site is best for injection?
IV Calcium Borogluconate
Place in sternal recumbency
Jugular vein
What is the problem with using the milk vein for injections?
Risk of haematomas
Lack of drainage
Lying on that area can cause abscesses
What is the best prevention strategy for milk fever?
Low calcium and high magnesium diet pre-calving
Maximise DMI
What does Zeolite do?
What is a risk of using it?
In which cows is it contraindicated?
Binds calcium in ration
Improves mobility of calcium in order to prevent milk fever
Risk of hypophosphataemia
Don’t use in lactating ration!
What is the difference between hypocalcaemia in sheep and cattle?
Sheep: Pre-lambing (stress)
Cattle: At/after calving (poor mobilisation of and drained calcium reserves)
- What can cause grass staggers/hypomagnaesemia?
2. What can cause it in calves?
- High potassium (e.g. lush grass), reduces Mg absorption and STRESS
- Unsupplemented all milk diet (no Mg)
What are 5 differential diagnoses for a cow/sheep found dead in a field?
- Lightening strike
- Electrocution
- Toxaemia
- ANTHRAX!
- HypoMg
What are 2 differences between milk fever and grass staggers?
Diarrhoea in hypoMg (milk fever - no faeces)
Flaccid paralysis in milk fever, but hypoMg convulsive/paddling
How is glucose produced?
How is lactose synthesised?
Via gluconeogenesis from proprionate (in Krebs cycle)
From glucose
What happens if there is insufficient proprionate?
Insufficient oxalo-acetate
Acetyl CoA can’t enter Kreb’s cycle, metabolised to Ketones
Where does metabolisation of ketones and fat deposition occur?
Liver
What are NEFAs/FFAs produced from?
What are they metabolised to in the liver?
Lipolysis of adipose tissue
Metabolised to Ketones
What are ketones an energy source for?
Muscle (not milk production or brain)
Name 3 ways insulin decreases blood glucose
- Increases uptake of glucose into cells
- Decreases gluconeogenesis
- Suppresses lipolysis and ketogenesis