Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MSK AM > Metabolic bone disease > Flashcards

Metabolic bone disease Flashcards

1
Q

What is Paget’s disease?

A

Localised disorder of bone turnover caused by increased bone resorption and formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is th bone like in Paget’s disease?

A

Bigger, less compact and more vascular

More prone to deformity and fracture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the aetiology of Paget’s disease?

A

Genetic
Environmental- possible chronic viral infection in osteoclast
Restricted Anglo-Saxon distrubution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What ar the signs and symptoms of Paget’s disease?

A

Bone deformity or fracture
Bone pain
Excessive heat over affected bone
Neuro complications eg nerve deafness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the treatment of Paget’s disease?

A

IV bisphosphonate therapy

Surgery in some cases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

When is Paget’s disease treated?

A

In skull or if symptomatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the complications of Paget’s disease?

A

Osteosarcoma in affected bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is rickets?

A

Insufficient mineralisation n children due to severe vit D or calcium deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the presentation of rickets?

A 
stunted growth
Failure to thrive
Bandy legs
LArge abdo
Large forehead
Wide joints at elbow, wrist and ankles
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is osteomalacia?

A

Insufficnent mineralisation once epiphyseal plates have fused due to severe vit D or calcium deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the signs and symptoms of osteomalacia?

A

Bone pain
Muscle weaknes
Increased falls risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is osteogenesis imperfecta?

A

Genetic disorder of connective tissue characterised by fractures bone from mild trauma or daily life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the types of osteogenesis imperfecta?

A

Type 1-4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is type 1 osteogenesis imperfecta?

A

Mildest form

Presents normally when child starts to walk but can be in adulthood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is type 2 osteogenesis imperfecta?

A

Most severe form

Lethal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is type 3 osteogenesis imperfecta?

A

Progressive deformity with severe bone dysplasia and poor growth

17
Q

What is type 4 osteogenesis imperfecta?

A

Similar to type 1 but more severe

18
Q

What is the aetiology of OI?

A

Defects in type 1 collagen

Genetic abnormality

19
Q

What are the signs and symptoms of OI?

A 
Multiple fractures
Growth deficiency
Defective tooth formation
Hearing loss
Blue sclera
Scoliosis
BArrel chest
Hypermobile
Easy bruising
20
Q

What is the management of OI?

A

Surgical fracture treatment
IV bisphosphonate
Genetic counselling

MSK AM (37 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions