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Drugs list > Mental health > Flashcards

Mental health Flashcards

1
Q

SSRIs

A

Sertraline, citalopram, fluoxetine

MoA - inhibition of serotonin (5HT) reuptake pump in synaptic cleft

Indications - depression, generalised anxiety disorder

Adverse effects - insomnia, nausea

Interactions - NSAIDs, lithium

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2
Q

Reversible inhibitor of Monoamine Oxidase type A (RIMA)

A

Moclobemide

MoA - Inhibits monoamine oxidase A, preferentially decreases breakdown of serotonin and noradrenaline

Indications - depression

Adverse effects - tachycardia

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3
Q

Tricyclic antidepressants

A

Amitriptyline, nortriptyline, dosulepin

MoA - Inhibition of noradrenaline and serotonin reuptake in synaptic cleft, H1 antagonist, M1 antagonist, adrenergic antagonist

Indications - Depression

Adverse effects - anticholinergic syndrome

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4
Q

Atypical antidepressants

A

Reboxetine - noradrenaline reuptake inhibitor

Venlafaxine - noradrenaline/serotonin reuptake inhibitor

Buproprion - noradrenaline/dopamine reuptake inhibitor

Agomelatine - melatonin agonist

Mirtazapine - alpha-2 antagonist

Indication - depression

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5
Q

Antipsychotics - classical (also known as first generation)

A

chlorpromazine, haloperidol

MoA - selective D2 dopamine receptor blockade

Indications - schizophrenia

Adverse effects - blurred vision, tremor, extrapyramidal symptoms, hypotension

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6
Q

Antipsychotics - atypical (also known as second generation)

A

Olanzepine, risperidone, quetiapine, clozapine, amisulpride

MoA - selective D2 dopamine and 5HT receptor blockade

Indications - schizophrenia

Adverse effects - extrapyramidal symptoms (less than classical antipsychotics), hypotension

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7
Q

Mood stabiliser

A

Lithium carbonate

MoA - unclear, possible neuronal calcium channel blockade

Indication - bipolar disorder

Adverse effects - tremor, hypothyroidism

Interactions - NSAIDs, ACE inhibitors

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8
Q

Cholinesterase inhibitors

A

Donepezil, galantamine, rivastigmine

MoA - inhibition of cholinesterase (reversible)

Indications - Alzheimer’s disease, mild to moderate dementia

Adverse effects - nausea, vomiting

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9
Q

NMDA receptor antagonist

A

Memantine

MoA - VD blocker of NMDA receptors

Indications - Alzheimer’s disease, moderate to severe dementia

Adverse effects - constipation, hypertension

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10
Q

Anxiolytics

A

Benzodiazepines (eg. lorazepam, midazolam) - GABA PAM (γ-subunit)

Buspirone - 5-HT1A partial agonist

Indication - anxiety and related disorders

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11
Q

Non-benzodiazepine hypnotic

A

Zopiclone

MoA - GABA PAM (γ-subunit)
Enhanced effects of GABA

Indication - insomnia

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Drugs list (24 decks)

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