Anti-Epileptic drugs Flashcards
Anti-epilepsy drugs
Sodium valproate, lamotrigine, carbamazepine, ethosuximide
MoA - Na+ channel blockers
Ethosuximide (Ca2+ channel blocker)
Indications - Epilepsy
Adverse effects - Nausea, blurred vision
Interactions - Macrolide antibiotics
Benzodiazepines
Lorazepam, midazolam, diazepam, zolpidem (BDZ-like)
MoA - GABA PAM (γ-subunit). Enhanced effects of GABA
Indications - Epilepsy, acute seizures
Adverse effects - drowsiness, dependence
Interactions - sedatives
BDZ antagonist
Flumazenil
MoA - antagonises GABA signalling
Indications - Reversal of BDZ sedation
Barbiturates
Phenobarbitone, pentobarbitone, primidone
MoA - GABA PAM (β-subunit)
Enhanced effects of GABA
Indications - Epilepsy, acute seizures
Adverse effects - drowsiness, fainting
Interactions - sedatives, anti-coagulants