Bone/calcium/anaemia

Question 1

Calcitonin

Answer 1

Therapeutic hormones

MoA - Inhibits mobilisation of calcium from bones

Indications - Osteoporosis, hypercalcaemia

Adverse effects - abdo pain

Interactions - antacids

Question 2

Bisphosphonates

Answer 2

Alendronate, pamidronate

MoA - Inhibits osteoclast function and bone resorption

Indications - Osteoporosis, Hypercalcaemia

Question 3

Drugs for hypocalcaemia

Answer 3

IV calcium gluconate, vitamin D, Parathyroid hormone

MoA - Restoration of calcium levels and metabolism

Indications - Vitamin D deficiency

Question 4

Selective oestrogen receptor modulator (SERM)

Answer 4

Raloxifene

MoA - Stimulation of oestrogen function in bone

Indications - Prevention of bone fractures

Adverse effects - Hot flushes

Interactions - Warfarin

Question 5

Monoclonal antibody

Answer 5

Denusomab

MoA - Inhibition of osteoclast function and bone resorption

Indications - Osteoporosis

Adverse effects - hypocalcaemia

Question 6

Ferrous sulphate

Answer 6

MoA - Iron provision

Indications - Iron deficient anaemia

Adverse effects - Constipation

Interactions - Antacids

Question 7

Folic acid

Answer 7

MoA - Supports nucleic acid synthesis

Indications - Folate-deficient anaemia

Question 8

Vitamin B12

Answer 8

MoA - Enzyme co-factor

Indications - Pernicious anaemia