Memory disorders Flashcards
Describe the relationship between subjective memory complaints and objective assessment?
Subject complaint does not necessarily predict memory performace, but may pre-date formal deficits in some cases of dementia
Define memory?
The processes used to acquire, store, retain and later retrieve information
What did the case of HM help us to understand about memory?
The role of the medial temporal lobe in memory
Describe the difference between short-term and long-term memory?
Short-term memory: immediate memory, ability to keep inofrmation online, working memory
Long-term memory: storing information over minutes, hours, years for later retrieval
Describe how memory can be broken down into different types?
Describe procedural memory?
Long term, implicit memory
Skill acquisition
Which types of memory typically do or do not break down in disease states?
Non-declarative (procedural) memory typically stays intact
Declarative memory typically breaks down
Describe episodic memory?
Autobiographical
Events in a personal context, including place, time and emotional tone
Describe semantic memory?
General facts that are not specific to the individual and are not contextual
Describe the main system in the brain that is important for memory?
Hippocampal system
Hippocampus, entorhinal cortex, perirhinal cortex
How are the different parts of the hippocampus important in different diseases?
Different areas of hippocampus can break down differentially in different diseases
Describe how memory differs in the left vs right hippocampus?
Differs depending on dominance
LEFT: verbal memory
RIGHT: non-verbal memory
Describe some general causes of memory impairment?
Degenerative disorders
Cerebrovascular disorders
Paroxysmal/transient disorders
Surgical resection
Briefyl describe the neuropathology of temporal lobe epilsepsy?
Hippocampal sclerosis: cell loss, gliosis (scarring), hardening
What type of memory disturbance do TLE patients generally present with?
Declarative memory disturbance
List some of the other midline structures (besides hippocampus) that are important in memory?
Anterior thalamus
Basal forebrain
Mesial temporal region
Mamillary bodies
Retrosplenial cortex
What is the major risk factor for Alzheimer’s disease?
Age
How does the pathology of Alzheimer’s disease change across its stages?
Pathology moves to different areas of the brain as symptoms become more apparaent
Describe the language impairment in Alzheimer’s disease?
Fluent, empty language
Circumlocution
