Matt Roser L4 Flashcards
What are the hemispheres of the brain separated by?
The longitudinal/sagittal fissure
How are the hemispheres of the brain connected?
by commissures, which are tracts of white matter
What is the biggest commissure?
Corpus callosum > 200 million axons (95% myelinated)
Where are subcortical commissures?
Between subcortical nuclei
Which cortices connect across the hemispheres?
Associative cortices
Homotopic connections
Across hemispheres to same region
Heterotopic connections
Across hemisphere to different region
Ipsilateral connections
To different regions within the same side of the brain
Midline fusion
Strict homotopy between primary cortices across the corpus callosum
Anatomical asymmetries of the brain (3)
Anterior right hem/posterior left hem overlap midline, Sylvian fissure longer in left and ascends more anteriorly in right, underlying regional size/myelinisation
How do we test each hemisphere of the brain? (3)
lateralised visual presentation, dichotic listening, fMRI statistical lateralisation map
Commissurotomy
Surgery separating the corpus callosum
Callosotomy
Surgery separates some or all of the corpus callosum in order to stop atonic seizures (drop attacks).
Disconnection syndrome
A collection of symptoms which appear when the corpus callosum is severed i.e. difficulty paying attention and slower processing of information
How do we assess hemispheric integration in individuals who have had a commissurotomy?
- Subcortical commissures and what info can be transferred
- partial callosotomy showing specificity of transfer
Partial or staged callosotomy - what part of the corpus callosum is responsible for what information transfer?
Anterior - semantic
Central - motor
Posterior - sensory
What has unilateral brain damage shown for language processing?
That in 97% RH and 70% LH, language centres are predominantly left-hemispheric
How is language processing presented in patients with split-brain disconnection syndrome?
language is predominantly left-hemispheric, and only in the right visual field can stimuli be named. The right hemisphere still has a lexical ability (knows what it is seeing) just not grammatical
Normal brain Non-word decision
Stronger in the right visual field and ear -> left hemisphere associated with faster and more accurate responses