Mannheimia and Bibersteinia Flashcards
What differentiates Mannheimia haemolytica and Bibersteinia trehalosi?
Mannheimia haemolytica is trehalose negative, while Bibersteinia trehalosi is trehalose positive
________ is the most important bacterial cause of respiratory disease in cattle and sheep
Mannheimia haemolytica
______ has also been associated with mastitis in sheep
Mannheimia haemolytica
What do the colonies of Mannheimia haemolytica look like?
They are smaller than P. multocida and do not have the same distinct musty odor
Also have a very distinct, thin zone of complete hemolysis
T/F All types of Mannheimia haemolytica produce cytotoxins
TRUE; this is also true for Bibersteinia trehalosi
The cytotoxin produced by Mannheimia haemolytica is toxic for ________
leukocytes and platelets of ruminants
The cytotoxin of Mannheimia haemolytica is considered a ______ toxin
RTX; punches holes in teh cell membrane
Low levels of M. haemolytica toxin ______ while high levels lyse the ________ completely
Affect the function of leukocytes
Leukocytes
Where is the normal habitat for Mannheimia haemolytica?
Upper respiratory tract of cattle and sheep
Transmission of Mannheimia haemolytica?
ingestion or inhalation; Inhalation is the most common
What is the form of Mannheimia haemolytica that affects cattle?
Biovar A serotype 1
Serotype 2 is also seen, but it is non-pathogenic
_____% of feedlot pneumonia cases are due to Mannheimia haemolytica biovar A serotype 1
90
What lesions do you see with Mannheimia haemolytica biovar A serotype 1 infections in cattle?
fibrinous pleuropneumonia that can be involved with shipping fever complex
Mannheimia haemolytica can be an important cause of _____ in sheep. It is referred to as blue bag, as it can become gangrenous
mastitis
T/F Mannheimia haemolytica is an important organism in swine and horse health as well
FALSE; isolated occasionally but nothing to call home about
T/F Killed bacterins provide sufficient immunity against Mannheimia hemolytica
TRUE; they need to be given early and have to be given twice
A normal, non-stressed calf is able to withstand low levels of ________
Mannheimia haemolytica
______ cells are very important in the lower respiratory tract for defense
Phagocytic
High numbers of Mannheimia haemolytica in the lung may allow the organism to ______ and cause severe _______
survive
pneumonia
Mannheimia haemolytica _____ is thought to be important in the development of pneumonia
cytotoxin
Understand why the leukotoxin of Mannheimia haemolytica can cause pneumonia
Basically it lyses leukocytes, which causes the release of lysosomal enzymes, which causes inflammation in the lung
Inflammed lung tissue is non-functional lung tissue
A successful humoral response against Mannheimia haemolytica requires antibody against what two things?
1: the cytotoxin; Can be IgA, IgM, or IgG
2: Cell surface components; efficient killing of the organism
______ is an organism that is very similar to Mannheimia haemolytica and produces an identical cytotoxin
Biberstieinia trehalosi
Bibersteinia trehalose is associated with ______ in dairy cattle, especially in the _______ portion of the US
severe respiratory disease
Northwest
