Francisella, Coxiella, Legionella Flashcards
What is the one species of Francisella we are concerned with?
Francisella tularensis
Fracisella is the cause of what?
tularemia or rabbit fever
The biovar ______ is found only in North America
tularensis
Francisella biovar ________ is distributed more widely and is fevered to as ______ fever as it is associated with this animal
palaearctica
beaver
Francisella biovar _____ is a cause of human disease
novicida
What are the hosts for biovar tularensis and biovar palaeartica?
tularensis: ticks, wild rodents, and rabbits
palaeartica: beavers
What is the only way Francisella is spread to humans?
Via contact with rabbit or beaver/rodent
Via deer fly or tick bite (most common)
T/F The infectious dose of Francisella is very low
TRUE
What is the route of infection of Francisella?
It gets in via an abrasion and goes to the LNs
Then migrates to liver, spleen, BM, forming granulomatous nodules which can ulcerate
What are the drugs you would use to treat Francisella?
Streptomycin or Gentomycin
What is the species of Coxiella we are concerned with?
Coxiella burnetii
Coxiella burnetii is an _________ bacterium that is closely related to _______ and Legionella
obligate intracellular
Francisella
Coxiella burnetii is the cause of ____ in humans and ______ in ruminants
Q fever
abortions and respiratory tract infections
What are the two phases of Coxiella burnetii and what is a unique feature of each?
Phase I: Highly infective
Phase II: less infective, appear when culutres are repeatedly passed through egg or tissue culture
Antibody against Phase ___ of Coxiella burnetii often appears first
II
