Malignant Neoplasms

Question 1

what is the MC primary malignancy of bone

Answer 1

Multiple myeloma

Question 2

punched out lesions indicate

Answer 2

MM

Question 3

Rain drop skull indicates

Answer 3

MM

Question 4

Test to confirm possible MM

Answer 4

Immunuelctrophoresis

Question 5

What kind of bone scan does MM have

Answer 5

COLD

Question 6

4 tests to confirm MM

Answer 6

1. M-spike of immunelectrophoresis
2. Reversal of A/G ratio
3. Bence Jones Protein
4. Elevated ESR

Question 7

swiss cheese appearance in skull indicates

Answer 7

lytic mets

Question 8

Special test for lytic mets

Answer 8

bone scan

Question 9

Labs for lytic mets

Answer 9

Alkaline phosphatase

Question 10

Age for Hodgkins disease

Answer 10

20-40

Question 11

Ivory white vertebrae with anterior body scalloping at age 20-40 indicates

Answer 11

Hodgkins

Question 12

Uni-lateral Hilar lymphadenopathy indicates

Answer 12

Hodgkin’s, need biopsy to confirm

Question 13

When biopsying for Hodgkins what is a Dead GIVE AWAY

Answer 13

Reed Sternberg cells

Question 14

Ivory white vertebrae in >40y.o.

Answer 14

blastic mets

Question 15

Alkaline phosphatase is ______ in blastic mets

Answer 15

ELEVATED, use a BONE SCAN to diagnose

Question 16

Osteitis deformans is aka

Answer 16

Paget’s

Question 17

Picture frame vertebrae indicates

Answer 17

Paget’s

Question 18

Banana fractures and bowing deformities are seen commonly with

Answer 18

Paget’s

Question 19

Cotton wool in skull indicates

Answer 19

Paget’s

Question 20

Blade of grass look indicates

Answer 20

Paget’s

Question 21

Ivory vertebrae in 50+ year old

Answer 21

Paget’s most likely

Question 22

Increased ___________________ ___________ in patients with Paget’s

Answer 22

alkaline phosphatase

Question 23

Most common malignancy found in children

Answer 23

osteosarcoma 10-30 y.o.

Question 24

What kind of periosteal reaction occurs in osteosarcoma

Answer 24

spiculated/radiating/sunburst

Question 25

What kind of bone scan in patient with osteosarcoma

Answer 25

HOT

Question 26

Osteosarcoma treatment

Answer 26

amputation, chemo, radiation

Question 27

Chondrosarcoma and Fibrosarcoma age

Answer 27

>40 y.o. creates a POPCORN matrix, spiculated/radiating/sunburst periosteal reaction

Question 28

MC found bones for Ewing's sarcoma

Answer 28

diaphysis of long bones

Question 29

An onion skin(laminated) periosteal reaction indicates

Answer 29

Ewing's sarcoma

Question 30

Age range for Ewing's sarcoma

Answer 30

10-30

Question 31

Treatment for Ewing's sarcoma

Answer 31

amputation, chemo, radiation

Question 32

Codman's triangle can be an indication of

Answer 32

Ewing's sarcoma

Question 33

what is a Chordoma

Answer 33

aberrant notochordal cell tumor, MC found in the sacrum, 2nd MC is skull