Malignancy Criteria

Question 1

what is the evaluation for malignancy

Answer 1

1. uniform or variable
2. well-differentiated or not
3. arranged or disorganized

Question 2

what is the general criteria for malignancy

Answer 2

1. increased cellularity
2. anisocytosis
3. macrocytosis
4. pleomorphism

Question 3

what is anisocytosis

Answer 3

variation in cell size

Question 4

what is macrocytosis

Answer 4

atypically large cells

Question 5

what is pleomorphism

Answer 5

variability in shape

Question 6

what is the most important part of the cell to look at when determining malignancy

Answer 6

nucleus

Question 7

what are the 3 things to look for in a cell’s nucleus when determining malignancy

Answer 7

1. anisokaryosis
2. macrokaryosis
3. multinucleation

Question 8

what is anisokaryosis

Answer 8

variation in nuclear size

Question 9

what is macrokaryosis

Answer 9

abnormally large nuclei

Question 10

what are some characteristics of malignant cell nucleolis

Answer 10

prominent
large
irregular shape
variable in size

Question 11

besides an abnormal nuclei, what else within a cell can help identify a malignancy

Answer 11

increased number of mitotic figures
abnormal mitotic figures

Question 12

true or false:
macrophages can sometimes be mistaken as neoplastic cells

Answer 12

true
their abnormally large cytoplasms along with their ability to combine and make a multinucleated cell can be tricky

Question 13

what ‘value’ can be used to determine if the nucleus is not within the normal/standard sizing

Answer 13

using the nucleus : cytoplasm ratio