Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology Block 5 > Major Histocompatibility Complex (MHC) BLOCK 6 > Flashcards

Major Histocompatibility Complex (MHC) BLOCK 6 Flashcards

1
Q

What kind of cells produce MHC?

A

All nucleated cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Human leukocytes antigens

A

Mom will produce antibodies to father WBC.

HLA responsible for tissue transplant rejection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is another name for HLA?

A

MHC. That’s what we use more

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

______ first identified as important in rejection of tissue transplant

A

MHC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What kind of cells produce MHC I

A

All nucleated cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What kind of cells produce MHC II

A

B-cells and Antigen presenting cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

CD-8 recognizes what kind of MCH

A

MHC I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What kind of MHC does CD4 recognize

A

MHC II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What kind of MHC do neutrophils produce

A

MHC I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Why does liver not have MHCI

A

Because it cleans things, sees a lit of foreign material

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Does placenta have MHC?

A

No, because fetus is foreign and you don’t want to attack a fetus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is a key player in the normal immune response

A

MHC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CD-8 recognizes

A

MHC class I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

CH-4 recognizes

A

MHC class II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Where is MHC located?

A

On the short arm of chromosome 6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What ar the 3 major loci of MHC class I

A

A, B, C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which MHC plays a bigger role in organ transplant

A

MHC I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are the three major loci for MHC II

A

DP, DQ, DR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is the one major loci for MHC I

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the one major loci for MHC II

A

DR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What T cell plays a big role in tissue rejection

A

CD 4

22
Q

Why is MHC class 1 omnipresent

A

Every cell become cancerous/infectious. Have to have way to clear cells that are not part of immune system

23
Q

Endogenous antigens

A

From within the cell.
MHC I, CD-8
Not phagocytized

24
Q

What kind of antigens for MHCI?CD8

A

Endogenous

25
Q

Exogenous antigens

A

Something that was phagocityzed and brought into the cell
MHC II
CD-4

26
Q

MHCI processing

A

Endoplasmic reticulum

27
Q

MHC II processing

A

Lysosomal

28
Q

What is the docking station for CD8 on MHC I

A

alpha-3

29
Q

When looking at a picture, how can you tel what is MHC I and MHC II

A

MHC II has two projections into the cell

MHC I has one projection into the cell

30
Q

What is the docking station for CD4 on MHC II

A

Beta 2

31
Q

MHC I T cell

A

CD8

32
Q

MHC II T cell

A

CD4

33
Q

T-cells cannot respond to what

A

Unprocessed antigens

34
Q

MHC I presented to

A

CD 8 (Tc cells)

35
Q

MHC II presented to

A

CD4 (Th cells)

36
Q

The portion of an antigen that is bound by an Ab or T cell receptor. Antigens are covered in these

A

Epitope

37
Q

A substance that us salable of reacting with a specific antibody but cannot induce the formation of antibodies unless bound to a carrier protein or other molecules

A

Hapten

38
Q

What are the two arms of he adaptive response

A
  • Antibodies bind to Ag

- T cell receptors bind to epitope:MHC complexes

39
Q

Antigens are phagocytized and digested in acidic ___________

A

Lysosomes

40
Q

MHC II: peptide complexes interact with and activate ______ cells that are specific for the peptide

A

CD4+

41
Q

T cell receptors

A

Closely associated with CD3 complex and accessory molecules. Helps with signaling

42
Q

What is required for T-cell receptor

A

CD3

43
Q

What stabilizes the CD3:TCR complex

A

Accessory molecules

44
Q

What are the two signals required for T cell activation

A
  • engagement of TCR with MHC:Ag

- engagement of co-stimulators molecules with their ligands

45
Q

Engagement of TCR with MHC:Ag alone

A

Anergy

46
Q

Engagement of co-stimulators molecules alone

A

Anergy

47
Q

What activates lymphocytes

A

IL-2

48
Q

When does T cell activate

A

When MHC II is presented on a macrophage

49
Q

____ cells promote cell mediate response

A

TH1 (MHC I presentation)

  • NK cells
  • IFN and TNF
50
Q

____ cells promote antibody mediate responses

A

TH2

  • B cell activation
  • IL4 and IL10
51
Q

Identify which (if any) of the following cells lack MHC I
A. Neutrophils
B. Lymphocytes
C. RBC

A

RBC

52
Q

MHC II presents antigens to this cell type

A

T helper lymphocytes

Immunology Block 5 (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions