Major Histocompatibility Complex (MHC) BLOCK 6 Flashcards
What kind of cells produce MHC?
All nucleated cells
Human leukocytes antigens
Mom will produce antibodies to father WBC.
HLA responsible for tissue transplant rejection
What is another name for HLA?
MHC. That’s what we use more
______ first identified as important in rejection of tissue transplant
MHC
What kind of cells produce MHC I
All nucleated cells
What kind of cells produce MHC II
B-cells and Antigen presenting cells.
CD-8 recognizes what kind of MCH
MHC I
What kind of MHC does CD4 recognize
MHC II
What kind of MHC do neutrophils produce
MHC I
Why does liver not have MHCI
Because it cleans things, sees a lit of foreign material
Does placenta have MHC?
No, because fetus is foreign and you don’t want to attack a fetus
What is a key player in the normal immune response
MHC
CD-8 recognizes
MHC class I
CH-4 recognizes
MHC class II
Where is MHC located?
On the short arm of chromosome 6
What ar the 3 major loci of MHC class I
A, B, C
Which MHC plays a bigger role in organ transplant
MHC I
What are the three major loci for MHC II
DP, DQ, DR
What is the one major loci for MHC I
B
What is the one major loci for MHC II
DR
What T cell plays a big role in tissue rejection
CD 4
Why is MHC class 1 omnipresent
Every cell become cancerous/infectious. Have to have way to clear cells that are not part of immune system
Endogenous antigens
From within the cell.
MHC I, CD-8
Not phagocytized
What kind of antigens for MHCI?CD8
Endogenous
Exogenous antigens
Something that was phagocityzed and brought into the cell
MHC II
CD-4
MHCI processing
Endoplasmic reticulum
MHC II processing
Lysosomal
What is the docking station for CD8 on MHC I
alpha-3
When looking at a picture, how can you tel what is MHC I and MHC II
MHC II has two projections into the cell
MHC I has one projection into the cell
What is the docking station for CD4 on MHC II
Beta 2
MHC I T cell
CD8
MHC II T cell
CD4
T-cells cannot respond to what
Unprocessed antigens
MHC I presented to
CD 8 (Tc cells)
MHC II presented to
CD4 (Th cells)
The portion of an antigen that is bound by an Ab or T cell receptor. Antigens are covered in these
Epitope
A substance that us salable of reacting with a specific antibody but cannot induce the formation of antibodies unless bound to a carrier protein or other molecules
Hapten
What are the two arms of he adaptive response
- Antibodies bind to Ag
- T cell receptors bind to epitope:MHC complexes
Antigens are phagocytized and digested in acidic ___________
Lysosomes
MHC II: peptide complexes interact with and activate ______ cells that are specific for the peptide
CD4+
T cell receptors
Closely associated with CD3 complex and accessory molecules. Helps with signaling
What is required for T-cell receptor
CD3
What stabilizes the CD3:TCR complex
Accessory molecules
What are the two signals required for T cell activation
- engagement of TCR with MHC:Ag
- engagement of co-stimulators molecules with their ligands
Engagement of TCR with MHC:Ag alone
Anergy
Engagement of co-stimulators molecules alone
Anergy
What activates lymphocytes
IL-2
When does T cell activate
When MHC II is presented on a macrophage
____ cells promote cell mediate response
TH1 (MHC I presentation)
- NK cells
- IFN and TNF
____ cells promote antibody mediate responses
TH2
- B cell activation
- IL4 and IL10
Identify which (if any) of the following cells lack MHC I
A. Neutrophils
B. Lymphocytes
C. RBC
RBC
MHC II presents antigens to this cell type
T helper lymphocytes
