Immune Manipulation Flashcards
Examples of immunosuppressants
- NSAIDs
- glucocorticoids
- antibodies
What are examples of immunopotentiators
- active and passive immunizations
- ILs
What is the differnce between immunosuppressants and immunopotentiators
Immunosuppressants inhibit the immune system and immunopotentiators activate immune system
What are the proinflammatory cytokines
- IL-1
- TNF-a
- TNF-b
- IFN-y
- IL-6
- IL-8
What is the effect of blocking TNF-a production or its action
Won’t produce T and B cells
Objective, not sure?
What is the site of action for NSAIDs in the arachidonic pathway
COX 1 and 2 pathway
What is the site of action of corticosteroids in the arachidonic acid pathway
Phospholipase A2.
What does low dose NSAIDs do
Selectively hits the TXA2 site. Baby aspirin good for people at risk for stroke and MI
Why are NSAIDS harmful to stomach
The shit down the PGI2 pathway which protects the stomach normally
What do you Rx steroids for
Pain, fever, inflammation, immune modulation
What do you Rx NSAIDs for
Pain, fever, inflammation
Ab derived from multiple B cells against multiple epitopes on a single antigen.
Poly clonal antibodies
What kind of Ab are used to treat primary antibody deficiencies
Polyclonal Ab
Antibodies derived from a single B cell against a single epitope on a single antigen
Monoclonal antibodies
What type of Ab has exceptional purity and specificity
Monoclonal