Immune Manipulation Flashcards

1
Q

Examples of immunosuppressants

A
  • NSAIDs
  • glucocorticoids
  • antibodies
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2
Q

What are examples of immunopotentiators

A
  • active and passive immunizations

- ILs

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3
Q

What is the differnce between immunosuppressants and immunopotentiators

A

Immunosuppressants inhibit the immune system and immunopotentiators activate immune system

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4
Q

What are the proinflammatory cytokines

A
  • IL-1
  • TNF-a
  • TNF-b
  • IFN-y
  • IL-6
  • IL-8
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5
Q

What is the effect of blocking TNF-a production or its action

A

Won’t produce T and B cells

Objective, not sure?

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6
Q

What is the site of action for NSAIDs in the arachidonic pathway

A

COX 1 and 2 pathway

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7
Q

What is the site of action of corticosteroids in the arachidonic acid pathway

A

Phospholipase A2.

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8
Q

What does low dose NSAIDs do

A

Selectively hits the TXA2 site. Baby aspirin good for people at risk for stroke and MI

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9
Q

Why are NSAIDS harmful to stomach

A

The shit down the PGI2 pathway which protects the stomach normally

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10
Q

What do you Rx steroids for

A

Pain, fever, inflammation, immune modulation

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11
Q

What do you Rx NSAIDs for

A

Pain, fever, inflammation

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12
Q

Ab derived from multiple B cells against multiple epitopes on a single antigen.

A

Poly clonal antibodies

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13
Q

What kind of Ab are used to treat primary antibody deficiencies

A

Polyclonal Ab

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14
Q

Antibodies derived from a single B cell against a single epitope on a single antigen

A

Monoclonal antibodies

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15
Q

What type of Ab has exceptional purity and specificity

A

Monoclonal

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16
Q

What is the difference between humanize and chimeric monoclonal Ab

A

Humanized is 95% human.
Clipped very end of FAB

Chimeric is 1/3 mouse (FAB), 2/3 human (FC)

Humanize is better

17
Q

What does the suffix Mab mean

A

Monoclonal Ab

18
Q

What does the infix of the name (before -mab) indicate

A

Mab source

19
Q

What does the suffix Li(m) mean

A

Immune

20
Q

Umab

A

Human (100%)

21
Q

Ximab

A

Chimeric (2/3 human)

22
Q

Zumab

A

Humanize (95%)

23
Q

What ar therapeutic monoclonal Ab classified as

A

Biological

24
Q

What is the mac daddy or proinflammatory cytokines

A

TNFa

25
Q

Adalimumab (humira)

A

TNF-inhibitor

Immune target human MAB

26
Q

Infliximab (regicide)

A

TNF-inhibitor

Immune targeted chimera mab