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Immunology Block 5 > Immunity Of The Eye BLOCK 6 > Flashcards

Immunity Of The Eye BLOCK 6 Flashcards

1
Q

Between lactoferrin, lysozyme, mucins, meibum, and IgA, which of these is innate and which are acquired?

A

All of them are innate except IgA. IgA is acquired

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2
Q

Sequesters essential iron and enhances lysozyme

A

Lactoferrin

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3
Q

Digests petidoglycan (bacterial cell wall) and found in all body secretions and egg whites

A

Lysozyme

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4
Q

What punches holes in the cell wall in eye immunity

A

Lysozyme

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5
Q

What are in all body secretions

A

Lysozyme and IgA

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6
Q

Secreted antibody that binds pathogen, is a dimeric Ab and the secretory pieces is joined by the J chain

A

IgA

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7
Q

How does IgA help prevent inflammation

A

It does not activate complement

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8
Q

What attenuated lysozyme

A

Lactoferrin

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9
Q

Glycoproteins that inhibit microbe attachment

A

Mucins

Traps them

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10
Q

Meibomian gland lipids that prevent evaporation of tear film, prevents tear spillage, and makes closed eyelids airtight

A

Meibum

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11
Q

What helps tears wash away microbes

A

Meibum

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12
Q

What allows tears to well and not spill

A

Meibum

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13
Q

When stressed, what do keratocytes of the corneal stroma produce

A

IL-6 and defensins

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14
Q

These have broad spectrum antimicrobial activity and enhance healing in eye immunity

A

Defensins

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15
Q

What kind of immunity is ACAID (anterior chamber associated immune deviation)

A

Active immune privileged

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16
Q

Why is ACAID active immune privileged

A
  • active tolerance
  • antigen injected into AC suppresses immune response
  • intraocular injected Ag is captured by APCs (transplant not rejected)
  • APCs migrate to spleen
  • regulatory T cells (Tregs) prevent classic Th1 type 4 hypersensitivity
17
Q

What is the major thing that ACAID does that makes it active immune privileged

A

Inhibits Th1

18
Q

What kind of uveitis will someone with MS most likely have?

A

Intermediate uveitis

  • people with MS have a low chance of getting it, but have a 10X more likely chance of getting it than someone who does not have MS
  • if you have not been dx with MS and you are dx with intermediate uveitis, you have a 10% chance of having MS
19
Q

What is uveitis

A

Inflammation of the uvea. Complement is in full swing here.

20
Q

Anterior uveitis

A

Front of the eye

21
Q

Posterior uveitis

A

Choroid

22
Q

Most common form of uveitis

A

Anterior

23
Q

Least common form of uveitis

A

Posteiror

24
Q

This type of uveitis involves the whole eye

A

Pan-uveitis

25
Q

Symptoms of uveitis

A
  • changes in vision
  • sensitivity to light
  • dark, floating spots
  • eye pain or redness
26
Q

Potential complications of uveitis

A

Glaucoma
Cataracts
Neovascularization

Immunology Block 5 (11 decks)

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