Immunity Of The Eye BLOCK 6 Flashcards
Between lactoferrin, lysozyme, mucins, meibum, and IgA, which of these is innate and which are acquired?
All of them are innate except IgA. IgA is acquired
Sequesters essential iron and enhances lysozyme
Lactoferrin
Digests petidoglycan (bacterial cell wall) and found in all body secretions and egg whites
Lysozyme
What punches holes in the cell wall in eye immunity
Lysozyme
What are in all body secretions
Lysozyme and IgA
Secreted antibody that binds pathogen, is a dimeric Ab and the secretory pieces is joined by the J chain
IgA
How does IgA help prevent inflammation
It does not activate complement
What attenuated lysozyme
Lactoferrin
Glycoproteins that inhibit microbe attachment
Mucins
Traps them
Meibomian gland lipids that prevent evaporation of tear film, prevents tear spillage, and makes closed eyelids airtight
Meibum
What helps tears wash away microbes
Meibum
What allows tears to well and not spill
Meibum
When stressed, what do keratocytes of the corneal stroma produce
IL-6 and defensins
These have broad spectrum antimicrobial activity and enhance healing in eye immunity
Defensins
What kind of immunity is ACAID (anterior chamber associated immune deviation)
Active immune privileged
Why is ACAID active immune privileged
- active tolerance
- antigen injected into AC suppresses immune response
- intraocular injected Ag is captured by APCs (transplant not rejected)
- APCs migrate to spleen
- regulatory T cells (Tregs) prevent classic Th1 type 4 hypersensitivity
What is the major thing that ACAID does that makes it active immune privileged
Inhibits Th1
What kind of uveitis will someone with MS most likely have?
Intermediate uveitis
- people with MS have a low chance of getting it, but have a 10X more likely chance of getting it than someone who does not have MS
- if you have not been dx with MS and you are dx with intermediate uveitis, you have a 10% chance of having MS
What is uveitis
Inflammation of the uvea. Complement is in full swing here.
Anterior uveitis
Front of the eye
Posterior uveitis
Choroid
Most common form of uveitis
Anterior
Least common form of uveitis
Posteiror
This type of uveitis involves the whole eye
Pan-uveitis
Symptoms of uveitis
- changes in vision
- sensitivity to light
- dark, floating spots
- eye pain or redness
Potential complications of uveitis
Glaucoma
Cataracts
Neovascularization
