Lymphoid System Flashcards
natural, rapid, non-specific
initiated by phagocytic activity of macrophages/neutrophils
innate immunity
produced by liver –> bind to receptors for macrophages/neutophils
complement proteins
recognize pathogen molecules –> binds to pathogen stimulating macrophages/neutrophils to kill
toll-like receptors
T-lymphatic like cells, usually infected, articulate macro/neurto
natural killer cells
initiated by very strong innate immune responses
granulocystes/agranulocytes, diapadesis –> enter CTs
diapadesis induced by cytokines; released in inflam site by macro/neutro
inflammation
acquired immunity, slower response
high specificity and memory
responds to specific antigens
meditated by B/T lymphocytes
adaptive immunity
generate B lymphoblasts
lg produce naive pre B-cell
lg induces apoptosis
naive B-cells leave bone marrow, ready to be activated
B lymphocytes
generate T lymphoblasts
TcR produce naive pre T-cell
TcR interacts with APC’s; induces apoptosis
naive T cells leave thymus, ready to be activated
T lymphocytes
primary lymphoid organ
dense irregular CT capsule
dense irregular CT/trabculae/septa radiate from outer capsicle, dividing to # of lobules
thymus
(lobule) site of developing T-lymphocytes
cortex
(lobule) site of Hassal’s corpuscules which are cluster of reticular ep. cells that produce cytokines that stim. T -lymphocyte develop
medulla
site of entrance of developing T cells from b. marrow + exit of naive T-cells to go to 2 lymphoid organs
post capillary venules
blood-thymus barrier to protect T-cells in cortex
Hassal’s corpsucules @ medulla
epithelial reticular cells
dense irregular CT + true reticular net-like CT (collagen II) stroma hold B/T lymphoblasts in place
lymph nodes
(lymph nodes) activated in cortical nodules to become either plasma or memory cells
B cells
