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CPR Test 1 > Lymphatic System I > Flashcards

Lymphatic System I Flashcards

1
Q

…… cells migrate from bone marrow to the thymus gland to mature and become immunocompetent

A

T-Cells

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2
Q

T-Cells destroy the antigen by using ……. or activating ……… cells

A 
Cytotoxic action (CD8+) 
B cells
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3
Q

➢ Produce interleukin 2 (IL2), interferon (gamma) and tumor necrosis factor (alpha) ➢ interact with CD8+ cells to destroy intracellular antigens (viruses & microorganisms).

A

CD4+ Helper Cells (TH1 cells)

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4
Q

➢ Produce IL 4, IL5 , IL10 and IL13

➢ interact with B lymphocytes to destroy extracellular antigens

A

CD4+ helper cells (TH2 cells)

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5
Q

Immunocompetent B cells activated by

A

CD4+ T lymphocyte

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6
Q

Natural killer cells attack ….

A

Virus infected cells and cancer cells

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7
Q

Types of Immune Responses

A 
Innate Response (Non-specific Immunity)
Adaptive Response (Specific Immunity)
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8
Q

Which immune response occurs through fast action of neutrophils, macrophages, mast cells & NK cells?

A

Innate Response (Non- Specific Immunity)

-Do not produce memory cells

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9
Q

Which immune response depends on initial recognition of antigens by B and T cells?

A

Adaptive Response (Specific Immunity)

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10
Q

Two Types of Adaptive Immune Response

A

Antibody Mediated Immunity

Cell Mediated Immunity

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11
Q

…… Immunity uses Specific T cells that specialize in cytotoxicity • Granzymes and perforins as an immune response

A

Cell Mediated Immunity

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12
Q

…….. Immunity uses helper T-cells, B-cells and Plasma cells that cause a release of antibodies that act on invading antigen as an immune response

A

Antibody Mediated Immunity

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13
Q

Types of Lymphoid Tissue:

A

Diffuse Lymphoid Tissue

Nodular Lymphoid Tissue

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14
Q

3 Primary Lymphoid Organs

A

➢ Bone Marrow ➢ Thymus ➢ GALT

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15
Q

3 Secondary Lymphoid Organs

A

➢ Lymph nodes ➢ Spleen ➢ Tonsils

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16
Q 
The following characteristics are associated with which lymphoid tissue: 
o Initial immune response 
o Found in lamina propria 
o Intercepts antigen 
o No capsule
A

Diffuse Lymphoid Tissue

Example: MALT (mucosa associated lymphoid tissue)

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17
Q

The following characteristics are associated with which lymphoid tissue:

➢Characterized by nodules / follicles
➢Primary nodule 
– mainly consists of small lymphocytes 
➢Secondary nodule 
– consist of germinal center(GC)- area where lymphocytes undergo proliferation.
A

Nodular Lymphoid Tissue

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18
Q

The paler region in Germinal Center (GC) of Nodular lymphoid tissue

A

Immature lymphocytes (lymphoblasts)

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19
Q

The ………….. region has FDCs-follicular dendritic cells and indicates lymphatic tissue response to antigen.

A

Germinal Center

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20
Q

The ……….. region consists of small lymphocytes around the GC

A

Mantle zone or corona

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21
Q

Within in the lymphatic nodule, reticular cells produce…

A

Reticular Fibers (stroma)

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22
Q

Within in the lymphatic nodule, B-lymphocytes are activated, proliferate, and turn into ……. and …….. cells

A

Plasma Cells and Memory Cells

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23
Q

Within in the lymphatic nodule, the two Antigen Presenting Cells (APCs) are…..

A

Macrophages and Dendritic Follicular Cells

24
Q

Dendritic Follicular Cells and Macrophages within in the lymphatic nodule present which antigens?

A

MHC I and II molecules

25
Q

Follicular Dendritic Cells within in the lymphatic nodule contain which molecules?

A

Harbors Ag-Ab complexes

Lack MHC II

26
Q

……… interact with helper CD4+ T lymphocytes to facilitate immune responses.

A

Antigen Presenting Cells (APC’s)

27
Q

Functions of Macrophages:

A
  1. APC
  2. endocytosis and partial digestion of protein and polysaccharide antigen before they present them on MHC II molecules to help CD4+T cells
  3. digest pathogenic microorganisms by lysosomal action
  4. produces multiple cytokines- lymphokines, complement, interleukins, acid hydrolases and lipases
28
Q

Macrophages, Kuppfer cells, dust cells, Langerhan cells and dendrtic cells (spleen & lymph nodes) are APC of the ……… system

A

Mononuclear Phagocytic System (MPS)

29
Q

……… is primary lymphoid organ located in the superior mediastinum.

A

Thymus

30
Q

Epithelial Component of the thymus

A

Epithelial Reticular Cells (ERCs)

31
Q

…….. run within the thymus to divide tissue as lobules. Each lobule has a cortical cap over portions of highly convoluted but continuous inner medullary tissue.

A

Trabeculae

32
Q

Parenchyma of the Thymus:

A

In Cortex:
- mainly immature T lymphocytes (thymocytes) & ERCs (epithelial reticular cells)
In Medulla:
- mature T lymphocytes & ERCs

33
Q

…… primary support cells in the cortex.

A

Epithelial Reticular Cells (ERCs)

34
Q

Epithelial Reticular Cells (ERCs) form a ……. which is held together by desmosomes

A

Cytoreticulum

35
Q

…… ensheath blood vessels in cortex and sequester the developing T cells from blood born antigens.

A

Epithelial Reticular Cells (ERCs)

36
Q

ERCs are Characterized by …….

A

Characterized by continuous capillaries

37
Q

The thymus cortex are made of:

A

Cortex of tightly packed lymphocytes and support cells (epithelial reticular cells)

38
Q

…….. has lower concentration of lymphocytes

A

Inner Medulla

39
Q

The Blood Thymus Barrier is only found in the…..

A

Cortex

40
Q

Within the Medulla, lymphocytes…..

A

Differentiate and enlarge

Mature T cells migrate into medullary blood vessels and efferent lymphatics

41
Q

ERC’s contract into spherical, degenerative masses

A

Hassall’s Corpuscle

42
Q

Hassall’s Corpuscles are found only in the ……… and consist of rings of degenerating epithelial reticular cells

A

Thymic medulla

43
Q

Disease: Absent Thymus Gland caused by defect in the development of the 3rd & 4th branchial pouches & arches.

A

DiGeorge Syndrome (22q11.2 Deletion Syndrome)

44
Q

DiGeorge Syndrome is also called CATCH 22 which stands for…..

A 
Cardiac Anomaly
Abnormal Faces
Thymic Aplasia
Cleft Palate
Hypocalcemia
45
Q

Kidney Shaped Organs that filters lymphatic fluid

A

Lymph Nodes

46
Q

………. mounts immune response by recirculation of lymphocytes (route of metastases)

A

Lymph Nodes

47
Q

Where arteries and nerves enter and veins and lymphatic vessels leave the node.

A

Hilum

48
Q

Afferent lymphatic vessel – drains lymph through …….

A

Convex margin

49
Q

…….. in the deep cortex and medulla allow for the transition of lymphocytes from the blood stream to lymph tissue

A

High Endothelial Venules (HEVs)

50
Q

The outer cortex of the thymus is mainly composed of ……..

A

Lymphatic nodules of B-cells

Few T lymphocytes, macrophages, reticular cells, and APCs

51
Q

Paracortex is the …………..

A

Area between cortex and medulla) that is primarily composed of T-cells where excess lymph is reabsorbed

52
Q

……. allow for the transition of lymphocytes from the blood stream to lymph tissue

A

Paracortex (deep cortex)

53
Q

Branched cordlike extension of dense lymphoid tissue 

Contain primarily B lymphocytes, plasma cells, reticular cells and macrophages

A

Medullary Cords

54
Q

Dilated spaces separating medullary cords
Contain lymph, few wandering macrophages 
Granulocytes maybe present when lymph node is draining an infected region

A

Medullary Sinuses

55
Q

The stroma of lymph node consists of….

A
  1. Reticular cells (modified fibroblasts) cytoplasmic extensions cover reticular fibers
  2. Framework for myeloid (bone marrow) and lymphoid (lymph nodes, spleen) organs
56
Q

Lymph node stained with ……..

A

Silver Stain

CPR Test 1 (20 decks)

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