Lymphatic system and hematopoietic organs Flashcards
What is the lymphatic system?
Tissues and organs which produce, store and carry white blood cells
What does the lymphatic system do?
Fight infections and other diseases
What does the lymphatic system include?
Bone marrow
Spleen
Thymus
Lymph nodes
Lymphatic vesels
What does the lymphatic system filter?
Pathogens from the blood
3 parts of the lymphatic system
Lymphatic
Lymph nodes
Lymphoid organs
What fluid does the lymphatic system clean?
The interstitial fluid/extracellular fluid
What is extracellular fluid similar to?
Plasma
Different name for white blood cells
Lymphocytes
Which are our infection-fighting cells?
White blood cells
Is the lymphatic system one way/unidirectional or bi-directional?
Unidirectional
Primary function of the lymphatic system
Transport excess interstitial fluid from the intertital space back to the blood circularion
What does the lymphatic system use to transport the interstitial fluid back to the blood circulation?
Thoracic duct
Does the blood circulation have a one way or bi-directional course?
Bi-directional
What are the lymphatic vessels that come before the lymph nodes called?
Afferent lymphatic vessels
What are the lymphatic vessels that come after the lymph nodes called?
Efferent lymphatic vessels
Do lymphatic capillaries have a continuous basal membrane?
No it has a discontinuous basal membrane
Where are the elastic fibers found?
Only the capillaries
What kind of junction I found in the lymphatic cappilaires?
Button like junction
What kind of junction I found in the lymphatic ducts?
Zipper like junctions (has to be tight)
Are there valves in the lymphatic vessels?
Yes
What is the part of the vessels between two valves called?
Lymphangion
Different name for Lymphangion
Primitive hearts
4 types of external compression of the lymphatic vessels
Skeletal muscles
Cardiac muscle
Smooth muscles
Intestinal peristalsis
What happens when there is lymphatic pump dysfunction?
Lowered lymph flow
Increased Edema formation
Increased inflammatory cytokines and cells retention and local immune deficiency
Does the lymphatic system have a central pump?
No
What does the right lymphatic duct drain?
The right upper part of the trunk, right upper limb and right side of the head and neck
What are lymphoid organs classified as?
Primary or secondary organs
Which are the primary lymphoid organs?
Thymus and bone marrow
What are the primary lymphoid organs responsible for?
The production and maturation of lymphocytes
Which are the secondary lymphoid organs?
Spleen
Peyer’s patches
Appendix
Tonsils
Lymph nodes
What are the secondary lymphoid organs responsible for?
Further maturation of lymphocytes and initial of immune
What kind of organs are lymph nodes?
Full organs
Where are lymph nodes located?
Along the course fo the lymphatic collectors
What do the lymph nodes contain?
Lymphocyte B
Lymphocyte T
Shape of lymph nodes
Ovoid/bean shape
Size of lymph nodes
few mm - 1 cm
Where does lymphocyte B originate?
Bone marrow
Where does lymphocyte T originate?
Thymus
Are lymph nodes solid or hollow organ?
Solid organ
What is the lymph node built up of?
Capsule
Parenchyma
Trabecular of the capsule hilum
What is the stroma of the lymph node made up of?
Dense connective tissue and reticular stroma
Where in the lymph node are the plasma cells found?
In the medulla
Where in the lymph node are the macrophages cells found?
The medulla
Where in the lymph node are the lymphocytes cells found?
The medulla
How many efferent vessels from each lymph node?
1
How many afferent vessels in each lymph node?
Several
When does the follicles goes from primary to secondary?
When the b-cells go from naive to memory b-cells
What does the cortex of an unstimulated lymph node consist of?
Primary follicles composed of naive B cells
What are naive B cells?
Small, mature lymphocytes with condensed chromatin and scant cytoplasm
What is the location of the maturation of T-lymphocytes?
Thymus
Where is the thymus located?
Mostly in the anterior mediastinum and small part in the neck
Retrosternal
Is the thymus paired or unpaired?
Unpaired
What is each lobe of the thymus formed by?
A cortex and a medulla
Name of the neck of the thymus
Cornua of the thymus
Name of the lobes of the thymus
Thymic lobes
What is found inside the capsule of the thyroid?
The parenchyma (lymphoid tissue)
4 cells types of the thymus
T lymphocytes
TEC (thyme endothelial cells)
Macrophages
Dendritic cells
What allows for thymus homing?
Markers of the cell surfaces
What is positive selection?
Survival signal
What is negative selection?
Death signal
2 types of early fatal TEC
cTEC (cortex)
mTEC (medulla)
In which bones is there bone marrow?
Long bone
How much of total body weight is made of bone marrow?
3-5%
Where does hematopoiesis take place?
Bone marrow
What does the spleen consist of?
Large encapsulated mass of vascular and lymphoid tissue
Where is the spleen situated?
Upper left quadrant of the abdominal cavity
Which is the largest secondary lymphoid organ?
The spleen
Main spleen function
Destroy aged erythrocytes, aged platelets and repair young erythrocytes
What is the color and consistency of the spleen?
Dark red
Soft
What takes over hemocatheresis if the spleen is removed?
The liver
2 surfaces of the spleen
Diaphragmatic surface (external)
Visceral surface (internal)
Which surface of the spleen is convex?
The diaphragmatic surface
Which ribs does the spleen project on?
9-11th
Which rib is at the mid axis of the spleen?
10th
4 impressions on the visceral surface of the spleen
Gastric impression
Renal impression
Pancreatic impression
Colic impression
3 borders of the spleen
Superior/anterior border
Inferior/posterior border
Internal border
How much is the spleen covered by the peritoneum?
Entirely
Which artery supplies the spleen?
Splenic artery
Which vein drains the spleen?
Splenic vein
Which is the largest branch of the celiac trunk?
The splenic artery
What is white pulp in the spleen made of?
Lymphoid tissue
What does the white pulp in the spleen do?
Immune response
What does the red pulp in the spleen do?
Filtration of the blood (hemocateresis)
What does the splenic artery branch into when entering the hilum?
Trabecular arteries