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Jason's Intersystem Block > Lymph Node Pathology > Flashcards

Lymph Node Pathology Flashcards

0
Q

3 secondary lymphoid organs?

A

lymph node
spleen
MALT

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1
Q

2 primary lymphoid organs?

A

bone marrow

thymus

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2
Q

3 places with MALT? mucosa associated lymphoid tissue

A

tonsils
GIT
airways

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3
Q

what is in paracortex of lymph nodes?

A

naive T-cells

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4
Q

what is in mantle zone of lymph nodes?

A

Naive B cells

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5
Q

what are in primary follicles? 3 things:

A
  1. naive B cells
  2. follicular dendritic cells
  3. T-cells
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6
Q

medullary cords in lymph nodes contain?

A

plasma cells

immunoblasts

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7
Q

sinuses in lymph nodes contain 4 things

A
  1. lymph
  2. macrophages
  3. eosinophils
  4. B&T lymphocytes
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8
Q

CD 20 belongs to?

A

B-cells

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10
Q

CD3 belongs to?

A

T-cells

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11
Q

BLC2 anti-apoptosis protein is due to what translocation?

A

14;18

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12
Q

what do CLL and SLL (small lymphocytic lymphoma) cells look like?

A

mature looking B-cells of naive/memory cell type

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13
Q

what happens in GC?

A

Naive B in mantle zone»centroblasts»centrocytes»immunoblasts»hypermutation/switching»medullary cord» plasma cell

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14
Q

where are follicular dendritic cells/CD4 helper T-cells located in the lymph node?

A

Germinal Centre

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15
Q

3 reactive lymphadenopathies?

A
  1. localised:TB
  2. systemic: viral: EBV, HIV, Measles, rubella
  3. non-infective: autoimmune
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16
Q

2 main causes of lymphadenopathy?

A

Reactive

Neoplastic

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17
Q

what causes large painful lymph nodes?

A

lymphadenitis from infection due to rapid expansion, stretching of capsule

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18
Q

when are lymph nodes not tender?

A

chronic non-specific lymphadenitis

19
Q

3 causes of chronic non-specific lymphadenitis

A
  1. follicular hyperplasia
  2. paracortical
  3. sinus histiocytosis
20
Q

what are the 2 primary tumours of lymphadenopathy?

A
  1. Hodgkin lymphoma

2. non-Hodgkin’s lymphoma

21
Q

what is more common cause of neoplastic lymphadenopathy?

A

secondary metastases

22
Q

what neoplasias metastasizes to lymph nodes? 3 kinds

A
  1. carcinomas
  2. melanomas
  3. germ cells
23
Q

what type of neoplasia doesn’t as readily metastasise to nodes?

24
Q

3 big classes causes of neoplastic lymphadenopathy

A
  1. primary tumour
  2. secondary tumour
  3. leukaemic infiltration
25
how to diagnose lymphoma gold standard? aspirate or biopsy?
biopsy
26
hodgkin lymphoma look like what cels?
Reed Sternberg cells resemble mature B-cell neoplasms
27
lymphoma cells are generally at what stage of development?
mature/post-bone marrow stage (peripheral)
28
blood involvement in lymphomas?
minimal peripheral blood involvement
29
2 kinds of non-Hodgkin lymphomas?
1. nodal | 2. extranodal
30
4 big lymphoma risk factors?
1. immunosuppression 2. autoimmune 3. EBV/H. pylori 4. environmental: chemo, rad
31
most follicular lymphoma translocations?
t(14-18) (over expression of BCL2)
32
what is Burkitt's lymphoma chromosomal translocation?
chromosome 8 | MYC oncogene: ovegrowth
33
role of EBV in lymphoma?
infects B cells need T-cells to induce latency loss of T-cell immunity>>increase viral proteins>>polyclonal Bcells>>lymphoma
34
clinical features of focal/generalised nodal lymphoma: B symptoms:
1. fever 2. night sweats 3. weight loss >10% from baseline in 6/12
35
when does hodgkin's lymphoma happen?
young adult, second peak in later life
36
hodgkin's lymphoma what characteristic cells
Reed-Sternberg cells
37
what is predominant type of hodgkin's lymphoma ?
nodular lymphocyte
38
what do Reed-Sternberg cells look like?
large cell, +++cytoplasm large bilobate nucleus prominent eosinophilic nucleoli
39
Non-hodgkin's lymphomas tend to be B-cell or T-cell?
B-cell (85%)
40
where are 'extranodal' Non-hodgkin's lymphoma happen?
Thyroid: hashimoto's Stomach: H.pylori other: brain, breast, lung, intestine
41
what are diffuse large B cell lymphoma cell types?
post-germinal centre B-cells: (no nodules) 1. centroblasts 2. immunoblasts
42
follicular lymphomas predominant cell type? architecture?
1. centrocyte-like | 2. nodular
43
follicular lymphomas immunophenotype?
CD19-20 | BCL2+

Jason's Intersystem Block (19 decks)

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