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Jason's Intersystem Block > Drug Synergy > Flashcards

Drug Synergy Flashcards

1
Q

How does drug synergy minimise drug toxicity? 2 reasons:

A
  1. reduce dose of individual agents

2. avoid treatment limiting unwanted effects

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2
Q

CCR5 antagonist?

A

maraviroc

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3
Q

GP41 HIV fusion bind drug?

A

enfuvirtide

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4
Q

what is zidovudine (AZT)?

A

NRTI

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5
Q

what is maraviroc?

A

CCR5 antagonist

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6
Q

what is enfuvirtide?

A

HIV fusion bind drug GP41

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7
Q

why HAART triple therapy?

A

avoid resistance

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8
Q

integrase inhibitor?

A

raltegravir

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9
Q

protease inhibitor?

A

saquinavir

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10
Q

what is raltegravir?

A

integrase inhibitor

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11
Q

what is saquinavir?

A

protease inhibitor

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12
Q

what is an NNRTI?

A

Nevirapine: takes out enzyme

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13
Q

what is a bifunctional drug?

A

two activities in the same compound

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14
Q

eg of pharmacokinetic ‘boosting’?

A

combining two protease inhibitors:
rotonavir inhibits CYP 3A4
longer action of lopinavir

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15
Q

Hep C new treatment called?

A

sofosbuvir: prodrug plus

ribavarin

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16
Q

what is sofosbuvir?

A

inhibitor of NS5B polymerase

17
Q

sofosbuvir cost?

A

70k per course

18
Q

when not drug synergy for antibiotics?

A

bacteriocidal with bacteriostatic

19
Q

gentamicin plus penicillins synergize how?

A

penicillin weaken cell wall

gentamicin goes in and inhibits ribosomes

20
Q

what is the flucytosine and amphotericin synergy for? how?

A

fungal

amphotericin: weaken cell membrane
flucytosine: inhibit DNA synthesis

21
Q

how do drugs synergize in cancer chemo?

A

Main cancer drug eg. cispltin

give with anti-emetic: ondansetron

22
Q

transplantation immunosupression induction of what cell depletion?

A

T-cell depletion

23
Q

why maintenance transplantation immunosupression use combo of drugs?

A

allows greater window if you come off them

24
Q

what is a calcineurin inhibitor?

A

cyclosporin

tacrolimus

25
Q

Why give oxycodone(agonist) with naloxone (antagonist)?

A

prevent constipation from the opioid

26
Q

is it all about the new drugs?

A

Nope, cleverer use of existing drugs

Jason's Intersystem Block (19 decks)

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