Drug Synergy Flashcards
How does drug synergy minimise drug toxicity? 2 reasons:
- reduce dose of individual agents
2. avoid treatment limiting unwanted effects
CCR5 antagonist?
maraviroc
GP41 HIV fusion bind drug?
enfuvirtide
what is zidovudine (AZT)?
NRTI
what is maraviroc?
CCR5 antagonist
what is enfuvirtide?
HIV fusion bind drug GP41
why HAART triple therapy?
avoid resistance
integrase inhibitor?
raltegravir
protease inhibitor?
saquinavir
what is raltegravir?
integrase inhibitor
what is saquinavir?
protease inhibitor
what is an NNRTI?
Nevirapine: takes out enzyme
what is a bifunctional drug?
two activities in the same compound
eg of pharmacokinetic ‘boosting’?
combining two protease inhibitors:
rotonavir inhibits CYP 3A4
longer action of lopinavir
Hep C new treatment called?
sofosbuvir: prodrug plus
ribavarin
what is sofosbuvir?
inhibitor of NS5B polymerase
sofosbuvir cost?
70k per course
when not drug synergy for antibiotics?
bacteriocidal with bacteriostatic
gentamicin plus penicillins synergize how?
penicillin weaken cell wall
gentamicin goes in and inhibits ribosomes
what is the flucytosine and amphotericin synergy for? how?
fungal
amphotericin: weaken cell membrane
flucytosine: inhibit DNA synthesis
how do drugs synergize in cancer chemo?
Main cancer drug eg. cispltin
give with anti-emetic: ondansetron
transplantation immunosupression induction of what cell depletion?
T-cell depletion
why maintenance transplantation immunosupression use combo of drugs?
allows greater window if you come off them
what is a calcineurin inhibitor?
cyclosporin
tacrolimus
Why give oxycodone(agonist) with naloxone (antagonist)?
prevent constipation from the opioid
is it all about the new drugs?
Nope, cleverer use of existing drugs
