HIV 3 Flashcards
4 types of HIV drugs
- fusion/entry
- reverse transcriptase inhibitor
- integrase inhibitor
- protease inhibitor
3 places for HIV attachment intervention?
- CD4
- coreceptor: R5 maraviroc, X4 AMD-11070
- fusion: T20 = enfuvirtide
what is reversible x4 and R5 selection?
If only give R5 drug, more X4 and vice versa
nucleoside is?
no phosphate groups on 5’ side
what is needed for substrate DNA polymerisation?
nucleotide triphosphate
Acyclovir is nucleoside analogue for?
guanosine
treat HSV
acyclovir lacks what?
3’ hydroxyl group needed to form DNA polymer
what is ribavirin?
broad spectrum viral guanosine analogue
ribavirin used in?
RSV
influenza
Lassa, Ebola
Hep C
what is NRTI?
nucleoside reverse transcriptase inhibitors for HIV-1
problem with NRTI for HIV?
drug resistance is used alone
can’t eliminate virus completely
first NRTI for HIV?
Zidovidine (AZT)
AZT/Zidovidine is what kind of analogue?
thymidine
commonality of NRTIs?
all lack the OH group on the 3’ position
what is NNRTI?
Non-nucleoside reverse transcriptase inhibitors
what to NNRTI target?
directly inhibit the RT enzyme
what do integrase bind to in HIV?
binds to viral cDNA and catalytically processes 3’ ends, to make Long teminal repeats (LTR) circles
protease inhibitors do what?
bind via peptidomimetics to enzyme active site preventing cleavage and thus maturation of HIV particle
name a NNRTI?
delavirdine
Zalcitabine is?
NRTI
what are indinavir and Nelfinavir and Ritonavir?
protease inhibitors
what is raltegravir?
integrase inhibitor
what is enfuvirtude (T20)?
entry inhibitor
long term complications of HAART?
lipoatrophy
lipodystrophy
neuropathy
