Cancer Genes Flashcards
Which genes in CML??
Philadelphia chromosome
Philadelphia chromosome translocation of which ones?
T22;9 Bcr-Abl
how to treat CML?
imatinib (Gleevec)
CLL what what protein overexpressed?
bcl-2, stops role in apoptosis
what causes the Bcl-2 to be over expressed in CLL?
loss of miRNA15a/16-1
how to treat CLL?
BH3-only mimetic
ABT-199
Burkitt’s lymphoma has overexpression of which transcription factor?
Myc
Burkitt’s lymphoma has which translocations?
T18;14
Burkitt’s lymphoma possible cause?
EBV/chronic inflammation
in order for Myc to proceed from G1 to S, you need?
cylins eg. cyclinD
if something is wrong with cell DNA and it’s trying to get from G1 to S, what happens?
p53 will intervene by either:
- Repairing
- inhibit growth/apoptosis
evading growth inhibitory signals from p53 happens in which lymphoma?
Burkitt’s lymphoma (Myc)
Autonomous growth signalling happens in which leukemias?
CML (Bcr-Abl)
ALL
evasion of apoptosis is hallmark in which cancer?
CLL
how would a virus like HPV and EBV cause cancer?
HPV: E6/7 can block p53
EBV: chronic inflamm promotes translocations via hypermutation in B-cells
myeloid neoplasms arise from?
hemopoietic progenitor cells
where do myeloid neoplasms usually occur?
bone marrow
what is a myeloproliferative disorder? example?
CML
it’s a production in a few categories of mature cells
myelodysplastic syndrome is what?
disorderly proliferation in bone marrow»lack of mature cells in blood
what cells in acute myeloid leukemias?
too many immature blasts in bone marrow
what is a lymphocytic leukemia? eg of a cancer?
CLL
there are solid tissue neoplasms, involved in bone marrow and blood
majority of lymphoid neoplasms are of which cell origin?
B-cells (85-90%)
can be T or NK cells
what is natural history of CML chronic myeloid leukemia?
slow progression
median survival of 3 years
accelerated phase
Blast crisis (thought ro originate from a pluripotent stem cell)
