loop diuretics Flashcards
1
Q
how do they act?
A
act by inhibiting the Na-K-Cl co-transporter NKCC in the thick ascending limb of the loop of henle, reducing the absorption of NaCl.
2
Q
examples of loop diuretics?
A
furosemide and bumetanide
3
Q
which membrane do they work on?
A
apical
4
Q
who may need a higher dose of loop diuretics to ensure a sufficient concentration?
A
patients with poor renal function
5
Q
indications of diuretics
A
acute and chronic heart failure
resistant hypertension
6
Q
adverse effects
A
hypotension hyponatraemia hypokalaemia hypomagnesaemia ototoxicity hypocalaemia renal impairment hyperglycaemia gout
