hypertrophic obstructive cardiomyopathy: features

Question 1

pathophysiology

Answer 1

the most common defect involves a mutation in the gene encoding B-myosin heavy chain protein or myosin-binding protein C.
Results in predominantly diastolic dysfunction
- left ventricle hypertrophy leads to decreased compliance which leads to decreased cardiac output.

Question 2

features of hypertrophic obstructive cardiomyopathy

Answer 2

• often asymptomatic
• exertional dyspnoea
• angina
• syncope
• sudden death
• jerky pulse
  ejection systolic murmur

Question 3

ECG findings

Answer 3

left ventricular hypertrophy
non-specific St segment and T-wave segment abnormalities
deep Q-waves
atrial fibrillation may occasionally be seen.