Liver Adds

Question 1

Study Summary of Indication of Hepatits B TTT in chronic Cases

Question 2

Indication of Hepatits B TTT in Acute Cases

Question 3

King’s College criteria for emergency liver transplantation

Question 4

King’s College criteria for emergency liver transplantation in ALF due to paracetamol

Question 5

King’s College criteria for emergency liver transplantation in ALF not due to paracetamol

Question 6

…… remains the mainstay of treatment for HFE-HC, despite the ….. of randomized trials

Answer 6

• Phlebotomy
• absence

Question 7

Iron depletion can …..

Answer 7

• improve fatigue and cardiac function
• stabilize liver disease
• reduce skin pigmentation

Question 8

Joint symptoms, however, respond …… to phlebotomy therapy and can …….

Answer 8

poorly, worsen

Question 9

Phlebotomy can safely be carried out in patients with …….. with histological improvement found in …….. on follow-up liver biopsy

Answer 9

• advanced fibrosis/cirrhosis
• 15% - 50%

Question 10

• Phlebotomy typically involves ……. induction venesection of ……. of blood aiming for a target serum ferritin of ……., followed by maintenance venesection ……… aiming to maintain ferritin ………
• If anemia is detected, …….

Answer 10

• weekly
• 400 - 500 ml
• 50 μg/L
• 2-4 times a year
• 50-100 μg/L.
• phlebotomy should be postponed until the anemia is resolved

Question 11

Adjunctive oral chelation therapy (e.g. ……..) can be used in severe disease (e.g. ……..) and in cases of secondary iron overload (e.g. ………) but it is ………

Answer 11

• deferoxamine
• juvenile haemochromatosis
• thalassemia
• Expensive, cumbersome, and associated with several adverse effects including blurred vision, tinnitus, and diarrhea