L8: Focal Liver Disease Flashcards

1
Q

Classification of Hepatic Tumors

A
  1. Benign
  2. Malignant
    - Primary
    - Secondary
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2
Q

Benign Hepatic Tumors

A
  • Hemangioma
  • More common in middle aged females especially on COC’s (>20 years)
  • Usually requires NO ttt unless it bleeds or 5cm (risk of Mg transformation)
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3
Q

Malignant Hepatic Tumors

A
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4
Q

What is Another name of HCC?

A

Hepatoma

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5
Q

Incidence of HCC

A
  • The commonest try malignant tumor of the liver
  • Age: more common> 40 years
  • Sex: more common in males (male: female ratio is 3: 1)
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6
Q

Predisposing factors for HCC

A
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7
Q

CP of HCC

A
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8
Q

Para-malignant (Para-neoplastic) syndrome in HCC

A
  • Distal manifestation of tumor without metastases d.t production of hormone-like substances leads to:
  1. Painful gynecomastia
  2. Hypercalcemia, polycythemia
  3. Hypoglycemia
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9
Q

Local Liver examination in HCC

A

Palpation: enlarged; hard, tender & nodular liver

Auscultation: Frictions rub (d.t Peri-hepatitis, arterial bruit (tumor is highly vascular)

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10
Q

Metastasis of HCC

A
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11
Q

Investigations for HCC

A
  • Lab
  • Rad
  • Cyto
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12
Q

Lab investigations for HCC

A
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13
Q

Rad Investigations for HCC

A
  1. Abdominal US,
  2. Triphasic CT & MRI with contrast
  3. Chest X-ray for metastases
  4. Barium Swallow & barium meal to show tumor extension
  5. PV venography, IVC venography
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14
Q

Triphasic CT in HCC

A
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15
Q

Bx in HCC

A
  • Liver biopsy guided by US the surest diagnostic method, but has a limited role now after developing of the investigation
  • Aspiration of the ascetic fluid & examination
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16
Q

DDx of HCC

A
  1. Other causes of enlarged nodular liver
  2. Other causes of enlarged tender liver
  3. Other causes of refractory ascites
17
Q

TTT of HCC

A
  • Prophylaxis
  • Curative
18
Q

Prophylaxis in HCC

A
  1. Prevention & treatment of HBV & HCV infection
  2. Avoiding Aflatoxins
19
Q

Curative TTT in HCC

A
20
Q

Effects of Chemotherapy in HCC

A

it causes remission in 1/3 of patients as Adriamycin

21
Q

SE of adiramycin

A

heart failure in normal heart

22
Q

What are indications of Liver Transplantation in HCC?

A