L8: Focal Liver Disease Flashcards
1
Q
Classification of Hepatic Tumors
A
- Benign
- Malignant
- Primary
- Secondary
2
Q
Benign Hepatic Tumors
A
- Hemangioma
- More common in middle aged females especially on COC’s (>20 years)
- Usually requires NO ttt unless it bleeds or 5cm (risk of Mg transformation)
3
Q
Malignant Hepatic Tumors
A
4
Q
What is Another name of HCC?
A
Hepatoma
5
Q
Incidence of HCC
A
- The commonest try malignant tumor of the liver
- Age: more common> 40 years
- Sex: more common in males (male: female ratio is 3: 1)
6
Q
Predisposing factors for HCC
A
7
Q
CP of HCC
A
8
Q
Para-malignant (Para-neoplastic) syndrome in HCC
A
- Distal manifestation of tumor without metastases d.t production of hormone-like substances leads to:
- Painful gynecomastia
- Hypercalcemia, polycythemia
- Hypoglycemia
9
Q
Local Liver examination in HCC
A
Palpation: enlarged; hard, tender & nodular liver
Auscultation: Frictions rub (d.t Peri-hepatitis, arterial bruit (tumor is highly vascular)
10
Q
Metastasis of HCC
A
11
Q
Investigations for HCC
A
- Lab
- Rad
- Cyto
12
Q
Lab investigations for HCC
A
13
Q
Rad Investigations for HCC
A
- Abdominal US,
- Triphasic CT & MRI with contrast
- Chest X-ray for metastases
- Barium Swallow & barium meal to show tumor extension
- PV venography, IVC venography
14
Q
Triphasic CT in HCC
A
15
Q
Bx in HCC
A
- Liver biopsy guided by US the surest diagnostic method, but has a limited role now after developing of the investigation
- Aspiration of the ascetic fluid & examination
16
Q
DDx of HCC
A
- Other causes of enlarged nodular liver
- Other causes of enlarged tender liver
- Other causes of refractory ascites
17
Q
TTT of HCC
A
- Prophylaxis
- Curative
18
Q
Prophylaxis in HCC
A
- Prevention & treatment of HBV & HCV infection
- Avoiding Aflatoxins
19
Q
Curative TTT in HCC
A
20
Q
Effects of Chemotherapy in HCC
A
it causes remission in 1/3 of patients as Adriamycin
21
Q
SE of adiramycin
A
heart failure in normal heart
22
Q
What are indications of Liver Transplantation in HCC?
A
