Liver Flashcards
Portal vein supplies ___ % of blood flow; hepatic artery supplies ___% of blood flow
75%; 25%
Portal vein supplies ___% of O2 supply; hepatic artery supplies ___% of O2 supply
50%; 50%
Portal perfusion pressure =
portal vein pressure - hepatic vein pressure
Normal portal vein pressure?
Portal HTN pressure?
7-10 mmHg
> 20-30 mmHg
Where is factor 3 produced?
Vascular endothelial cells
Where is von willebrand factor produced?
Vascular endothelial cells
Where is factor 4 produced?
Calcium comes from diet
Vit K is required to synthesize what factors?
2,7,9 & 10 (1972)
What cells produce factor 8?
Sinusoidal cells & endothelial cells (NOT hepatocytes)
The liver produces all the plasma proteins except for ____
Immunoglobulins
_____ is a reservoir for acidic drugs
Albumin
____ is a reservoir for basic drugs
Alpha-1 acid glycoprotein
What 3 factors does the MELD score examine?
Bilirubin, INR, and serum creatinine
What 5 factors does the Child-Pugh score examine?
Albumin
PT
Bilirubin
Ascites
Encephalopathy
What does the hepatic arterial buffer system do?
When there’s a reduction in portal vein blood flow, the buffer response compensates by increasing flow through the hepatic artery. Impaired in severe liver dz
Why does liver dz lead to hyper dynamic circulation?
Impaired ability to clear vasodilation substances from systemic circulation. (High CO and low SVR)
