IV Anesthetics Flashcards
Propofol infusion syndrome is categorized by the presence of?
Bradycardia & metabolic acidosis
What preservative is used in Diprivan?
Disodium edetate
What preservative is used in generic Propofol?
Sodium metabisulfite
What population is affected by the preservative in Propofol? What preservative?
May cause bronchospasm in pts with asthma
Metabisulfite
_____ ____mg IV can reduce itching caused by spinal opioids & cholestasis
Propofol 10 mg
Propofol ____ mg can be used to treat PONV
10-20
What enzyme converts fospropofol to Propofol?
Alkaline phosphatase (found in vascular endothelium)
What is the bolus dose of fospropofol?
6.5 mg/kg
What is the onset of fospropofol?
5-13 min
Ketamine dissociates the ____ (sensory) from the _____ (awareness)
Thalamus; limbic system
What receptors does ketamine work on?
NMDA
Opioid
MAO
Serotonin
NorEpi
Muscarinic
Na channels
What is an active metabolite if ketamine?
Norketamine
Thipoental is a thionarbiturate with a ____ molecule in the second position
Sulfur
What drugs should you avoid for acute intermittent porphyria?
Barbiturates
Etomidate
Ketamine
Ketorolac
Amio
CCBs
Birth control pills
What is the induction dose for methohexital?
1-1.5mg/kg
What barbiturate is the gold standard for electroconvulsive therapy?
Methohexital
What are 2 treatments for infra-arterial injection of thiopental?
Local injection with phentolamine or phenoxybenzamine
Or
Sympathectomy (Stellate ganglion block or brachial plexus block)
Precedex decreases ____, which inhibits the ____ ____ in the pons (causing sedation)
cAMP;
Locus coeruleus
Dexmedetomidine provides sedation from the ____ and analgesia from the ____
Locus coeruleus;
Dorsal horn of spinal cord
What is the maintenance infusion rate for dexmedetomidine?
0.4-0.7mcg/kg/hr
What is the initial dose of flumazenil?
0.2mg
B
What drug is this
Fospropofol
What drug is this
Ketamine
What drug is this
Etomidate
What drug is this
Thiopental
What drug is this
Dexmedetomidine
What drug is this
Midazolam
What are 4 signs and symptoms of serotonin syndrome?
Hyperthermia
Mental status changes
Hyperreflexia
Seizures
