Lipid Disorders

Question 0

Lovastatin
Simvastatin
Provastatin
Atorvastatin
Rosuvastatin

Answer 0

Statin

Last two- high potency

Question 1

Statins

Answer 1

Competitive inhibitors of Hmgcoa reductase inhibitors
Increase synthesis of cholesterol in liver

Reduce LDL receptor expression in liver
-stabilize plaque 
-anti inflammatory 
-anticoagulant 
-increase NO synthesis
Increase paraoxonase

Hepatic sham thesis of VLDL is reduced

Increase in hdL

A.e. Myopathy, heptatoxicity

Question 2

Cervastatin

Simvastatin

Answer 2

Can cause severe myopathy

Cervastatin- rhabdomyolysis and it’s resultant renal failure *****

Higher risk in people using vibrates like gemfibrozil****

Question 3

Cholestyramine

Colestipol

Answer 3

Bile acid sequestrants resins, increase fecal excretion of bile salts and cholesterol

A.e. Constipation, bloating , vitamin deficiency

Decrease LDL ^LDLR ,increase HDL, slight^ VLDL

I

Question 4

Ezetimbe

Answer 4

Decrease cholesterol absorption in brush border of small inteStine, leads to increase in LDL cholesterol uptake -
Decrease ldl and TG
A.e. Gi disturbances

Question 5

Fenifibrate
Gemfibrozil
Clofibrate

Answer 5

Peroxisome proliferator activated receptor alpha-ppara agonist

-activate lipoprotein lipase reduce
Degrade VLDL reduce TG**
-reduce LDL

A.e.-colfibrate gallstones
Myopathy with g drug

Myopathy, rhamdo, renal failure if taking statin with gemfibrozil*

Question 6

Niacin

Nicotinic acid

Answer 6

Broad spectrum use
Increased hdl *best
Reduce tg**,
A.e. Cutaneous dialator, flushing-and itching-reduce–take Asa or NSAIDs ,liver dysfunction, hoist , hyperglycemia

Question 7

Streptokinase

Answer 7

Fibrinolytic drugs
Antigenic
Non fibrin specific