Hypertention Flashcards
Clonidine
Alpha 2 receptor agonist
- level of brain to decrease sympathetic
- acts in nucleus if tractus solitarius
- activates imidazoline receptors agonist-
- A.E. Sedation and drowsiness
- stop abruptly - hypertensive crisis
Methyl dopa
False neurotransmitter
Acts as alpha 2 receptor
Useful in pregnant hypertensive woman
Work in cns so A.E. Sedation and drowsiness
Coombs test and hemolytic anemia
Xerostomia
Clonidine 50
Methyl 10
Cns mediated
Reserpine
Blocks NE from getting into vesicles
A.E- pns dominance
-depression, Parkinsonism ,galactorrhea
Guanethidine
Block release of NE
a.E. Severe postural hypotension, loss of sympathetic effect, I opposed PNS activity( no ejaculation)
Alpha 1 blockers
Proazosin Terrazosin Doxazosin 3rd line drugs in HTN Useful in BPH Long term- weight gain
Proazosin
Terrazosin
Doxazosin
Dilate both resistance and capacitance vessels
a. E. Postural hypotension -first dose phenomenon , cerebral ischemia,
* do not use sildenafil (phosphodiesterase) inhibitors with them or will cause severe hypotension
Phentolamine
A1 and a2 blockers
Alpha 2 agonist
Most used
B blocker
Only 1st choice if CAD
Otherwise no
A1b1 blockers
Carbedilol
Labetalol
Nebivolol
B1 blocker
Acts as vasodilator
Partial agonist beta blocker
Labetolol
Pindolol
Propanolol
Beta blocker
Cross the bbb
Hyperthyroidism
Sotalol
Beta blocker k channel
Class 3 anti arrhythmic
