Haemopoetic Agents

Question 0

Ferrous sulfate
Ferrous gulconate
Ferrous fumarate

Answer 0

Oral iron preparations

A.e. Epi gastric pain,nausea vomiting, constipation,teeth stain, metallic taste

Question 1

Acute iron poisoning

Answer 1

Tx: deferrioxamine -iron cheating agent

Common in infants and children
-metabolic acidosis coma,death

Question 2

Parenternal iron

Answer 2

Iron dextran- IV / IM
Sodium ferric gluconate complex-only IV
Iron sucrose -only IV

A.e- iron dextran -allergic severe response

Uses:pregnant, people on erythropoietin iron def anemia

Question 3

Cyanocobalamin

Hydroxyl cobalamin

Answer 3

Vitb12
Given parentally once a month
Need intrinsic factor I
Absorbed in ileum

Use in megaloblastic anemia , pernicious anemia

Question 4

folic acid

Answer 4

Folic acid
Dihydrofoilc acid
Tetrahydrofolic acid

Use in megaloblastic anemia, alcohol liver disease and anemia caused by drugs phenytoin, sulfinamides, methotrexate, INH

Question 5

Methotextrate toxicity

Answer 5

Leucovorin / citrocorum factor/ folinic acid

DHFR inhibitor **

Question 6

Erythropoietin

Darbopoieten

Answer 6

For anemia of chronic renal failure***, chemotherapy patients, AIDS patients -zidovudine

Question 7

Filgrastim

Answer 7

G-csf (granulocyte colony stimulating factor )

Treat neutropenia from anticancer drugs

A.e. Bone pain and allergic reaction

Question 8

Sargramostim

Answer 8

Granulocyte/ macrophage colony stimulating factor -GM-CSF

Used for- Myeloid reconstruction
Bm transplantation
Neutropenia
AML

Question 9

Interleukin 11- oprelvekin

Answer 9

Stimulate formation of megakaryocytes and increase their number in peripheral blood

Use for thrombocytopenia after a cycle of chemotherapy