Hypo And Hyperthyroidism

Question 0

Liothyronine-T3

Answer 0

More potent
Faster acting but short half life
Injectable -immediate response

Question 1

Levothyroxine-T4

Answer 1

Orally. Long half life
30-60 minutes before food

Use for hypothyroidism
Hashimotos, myxedema, people after I131

Question 2

Perchlorate

Thiocyanata

Answer 2

Inhibit uptake of iodine

Can cause aplastic anemia

Question 3

Monovalent anions

Answer 3

Resemble iodide
Inhibit transport of iodide into thyroid

Can cause Aplastic anemia

Question 4

Propythiouracil
Methimazole- for 18 months

Are Thiamides

Answer 4

Inhibits thyroid peroxidase so inhibits coupling of MIT and DIT -block synthesis of T3 and T4

Used in hyperthyroidism

P -safer in pregnancy Nd thyroid storm but otherwise M is safer

A.e. P-severe hepatotoxitity

Question 5

Radioactive 131I

Answer 5

Concentrated thyroid-emits b radiation

Used in hyperthyroidism

A.e. Contradicted in pregnanc, hypothyroidism ,

Question 6

Propranolol

Answer 6

B blocker used in hyperthyroidism

B1 for tachy
B2 for tremor

Decrease t4 to T3

Question 7

Thyroid storm or crisis

Answer 7

Use propylthiouracil,propranolol, potassium iodine,glucocorticoids

Question 8

Iodine Na/k and ilugol iodines

Answer 8

Inhibit secretion if T4 and T3 , ‘
MIT and Dit deionized

Decrease size of thyroid -good to use before surgery

Question 9

Glucocorticoids

Answer 9

Decrease T4 to t3