Gonadal Hormones

Question 0

Diethylstibestrol -DES

Answer 0

Synthetic non steroidal estrogens
To prolong pregnancy in woman
But teratogenic affect

Question 1

Estradiol
Estrone
Estriol

Answer 1

Natural estrogens

Question 2

Ethyinyl estradiol
Mestronol
Quinestrol

Answer 2

Synthetic steroidal estrogens

• Used for post menopausal hormone therapy
• Contraceptives
• primary hypogonadism

Question 3

Medroxy progesterone acetate

Answer 3

Synthetic progesterone derivatives

Add to conjugated estrogen/ ethinyl estradiol in menopausal women** so don’t increased risk of endometrial cancer

Question 4

Megestrol

Answer 4

Synthetic progesterone

Question 5

Hydroxy progesterone caproate

Answer 5

Synthetic progesterone

Question 6

19 norestestosterone derivatives

Progestin drug used as contraceptives, post menopausal rep.ther.

Answer 6

Norethindrone
Levonorgestrel
Desogestrel
Norgestimate

Question 7

Progesterone

Answer 7

Helps the fertilized ovum survive

Prevents endometrial carcinoma

Question 8

Depot medroxy progesterone acetate

Answer 8

Progestin for contraception every three months

Injectable

Question 9

Levonorgestrel

Answer 9

Progestin implants for contraception s

Oral-within 24 hours for post coital

Question 10

Norethindrone

Answer 10

Oral progestin contraceptives

Question 11

Mifepristone

Answer 11

Postcoital contraception along with misoprestol pge1

Plan b

Block progesterone receptors -prevents implantation within 72 hours
-terminate pregnancy <49 days
Hcg levels fall, progesterone falls,

Question 12

Clomiphene- SERM

Answer 12

Competitive antagonist at estrogen receptors in pituitary and hypothalamus

• inhibit estradiol
• increases secretion if FSH/LH
• induces ovulation

Use-infertility,invitro
A.e.many babies

Question 13

Tamoxifen citrate-SERM

Answer 13

Antagonist of estrogen receptors -breast

Use:diagnosis if **breast cancer, prevents osteoporosis

A.e.increase risk of endometrial cancers, hot flashes,n&v

Question 14

Ralpxofene- SERM

Answer 14

Partial agonist estrogen in bone, antagonist in endometrium and breast
*lower risk of breast cancer, no endom. Hyperplasia,

Use: post menopausal osteoporosis
No endometrial hyperplasia**

A. Hot flashes, n and v

Question 15

Ospemifene -SERM

Answer 15

Agonist in bone and vulvovagina
Antagonist in breast and endometrium

Used for :vulvo vagainal atrophy with dyspareunia**

Question 16

Bazedoxifene and conjugated estrogens

Answer 16

SERM agonist in bone but antagonist in breast and endometrium

-block estrogen effect

Use:post menopausal osteoporosis
And prevents hot flashes **

Question 17

Anastrozole

Letrizole

Answer 17

Aromatase inhibitors
Competitive antagonists

Prolong survival in breast cancer - more effective than tamoxifen

Question 18

Exemestane

Answer 18

Aromatase inhibitors
Binds covalent lay as suicide enzyme inhibitors

Prolongs survival of breast cancer

Question 19

Methyl testosterone

Fluoxymesterone

Answer 19

Oral androgen testosterone

Question 20

Testosterone propionate

Testosterone curio ate

Answer 20

Intramuscular testosterone

Question 21

Flutamide- anti androgen

Answer 21

Used for prostatic carcinoma

Question 22

Cyproterone

Answer 22

Used in precocious puberty, prostatic cancer,hirsutism in woman

Question 23

Sprinolactone- anti androgen

Answer 23

Use for husutism in woman

Question 24

Flutamide Cypoterone Spiromolactone

Answer 24

Anti androgens | Competitive inhibitors that block testosterone at target tissue

Question 25

Finasteride

Answer 25

5a reductade inhibitor. | Use for benign prostate herperttophy and make pattern baldness

Question 26

Danazol

Answer 26

Suppression of gonadotropin secretion, testicular and ovarian function Uses for endometriosis, menorrhagia , fibrocystic breast disease