Hypothalamic And Pituitary

Question 0

Somatostatin

Answer 0

GHiH
Made by hypothalamus and pancreas
- inhibit release of GH, insulin, glucagon, gastrin, constricts splanchnic blood vessels

Question 1

Somatotropin
Somatrem

Aka Growth Hormone

Answer 1

Promotes bone growth-
**somatomedin c or insulin growth factors (igf-1) by liver

Use: GH deficiency, turners, chronic renal failure, severe catabolic states-AIDS

A.e. Edema, carpel tunnel

Question 2

Octreotide

Lanreotide

Answer 2

GH inhibiting
Long acting
Given subcutaneous injection
Use for 
Acromegaly, diarrhea of carcinoid syndrome , esophageal varies, glucaganoma, gastrinoma

Question 3

Urofollitropin

Fillitropin alpha and beta

Answer 3

FSH
Induce follicular growth
Develop ovum
Secrete estrogen 
Regulate spermatogenisis in men

Question 4

Lutropin

Answer 4

Lutenizing hormone

Ovulation, maintain corpus luteum, progesterone secretion, testosterone secretion

Question 5

Gonadorelin
Leuprolide- use in prostate cancer
Gosperelin
Buserelin
Histerelin
Nadarelin

Answer 5

GnRH -release FSH and LH

Used in prostate cancer -leuprolide and flutamideA.e. Andropause

Endometriosis and precocious puberty, promote overian hyperstimulation in IVF

Question 6

Cetrorelix

Gainirelix

Answer 6

GnRH antagonist

Used in controlled ovarian hyperstimulation as part of invitro
-prevent premature surges of LH

Question 7

Prolactin

Answer 7

Maintains and initiates lactation

Growth and development of breast

Question 8

Bromocriptine
Pergolide
Cabergoline

Answer 8

Dopamine agonist- synthetic ergot alkaloids
Inhibits prolactin

Used for pituitary tumor-
In acromegaly to decrease GH **
Parkinson’s, suppress lactation, gynaecomastia, infertility

Question 9

Antipsychotic - chlorpromazine

Haloperidol

Answer 9

Dopamine antagonist increase prolactin

Question 10

Oxytocin

posterior pH

Answer 10

Induce uterine, present post partum haemorrhage, for milk let down
IV

-contradicated in fetal distress, cephalopelvic disproportion

Question 11

Vasopressin (ADH)

Posterior pituitary hormones -

Answer 11

V1 receptors in vessels -vasoconstriction

V2- receptors in collecting ducts - antidouresis

Desmopressin More V2 activity - agonist , nasal spray for central DI,bleeding esophageal varies, haemophilia and von willibrand diseas

Question 12

Conivaptan

Tolvaptan

Answer 12

Vasopressin ADH antagonist

For SIADH

Question 13

Gonadorelin

Answer 13

GnRH ^ for infertility

Pulsatile administration

Question 14

Pegvisomant

Answer 14

GH receptor antagonist for treatment of acromegaly

Question 15

Gonadotropin adverse effect

Answer 15

Ovarian hyper stimulation syndrome

Multiple pregnancies