GOUT

Question 0

Indomethacin

Answer 0

NSAID used in gouT

Acute treatment for gout

Question 1

Colchicine

Answer 1

Used in acute stage of gout **TQ
-binds to Tubulin
-inhibits neutrophil migration
A.E- GIT irritation including diarrhea

Question 2

Probenecid

Answer 2

Uricosuric

Reduced load of uric acid by increasing in urine
Not very potent

Question 3

Losartain

Answer 3

Uricisurics

-weak
Helps reduce body load of uric acid increasing in urine

Question 4

Rasbuticase

Pegloticase

Answer 4

Provides exogenous uricase

• only used for patient flooded with uricase as a result of chemo of lymphoma and leukemia
• can develop antibodies to them

Question 5

Allopurinol

Answer 5

Decrease uric acid synthesis

• competitive inhibitor of Xanthine
  Can cause severe hypersensitivity

TQ !!

Question 6

Febuxostat

Answer 6

Decrease synthesis of uric acid

• non competitive inhibitor of Xanthine oxidase
• more potency and efficacy than allopurinol
• no allergen city

Question 7

Steven Johnson’s syndrome

Answer 7

Association with HLA-B*5801 and allopurinol induces SJS/TEN

-screen This in patients

Question 8

Antiinflammatories

Answer 8

Indomethacin

Colchicine

Question 9

Probenecid
Losartain
Rasburicase
Pegloticase

Answer 9

Urosuric
Agennt

1) -increase loss in urine
2) exogenous uricase- chemo

Avoid salicylayes

Question 10

Ferbuxostat

Allopurinol

Answer 10

Xanthine oxidase inhibitors for gout - decrease synthesis of uric acid