Lipid Derived Autacoids - Eicosanoids Flashcards by Лили Ауси | Brainscape

Q

Explain Eicosanoids

A

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Q

What are the products of COX called

A

Prostanoids

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Q

What are the types of prostanoids

A

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Q

What is the function of PGI2

A

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Q

What is the function of PGD2

A

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Q

What is the function of PGE2

A

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Q

What is the function of PGF2a

A

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Q

What is Thromboxane A2

A

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Q

What are the COX isoforms

A

COX 1
COX 2
COX 3

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Q

Explain COX1

A

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Q

Explain COX2

A

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Q

Explain COX3

A

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Q

How are leukotriens produced

A

From arachidonic acid by lipoxygenase

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Q

What are the receptors of LTB4

A

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Q

What are the function of the leukotriens members

A

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Q

List the prostaglandin analogues

A

Q

What is the use of Dinoprostone

A

Q

What is the use of alprostadil

A

Q

What is the use of misoprostol

A

Q

What is the use of latanoprost

A

Q

What is the use of Epoprostenol

A

Q

What are the eicosonoids inhibitors

A

Corticosteroids
Aspirin and other NSAIDs

Q

What does corticosteroids inhibit

A

Q

What does Aspirin and other NSAIDs inhibit

A

Q

What are the leukotriene inhibitors

A

Zileuton
Montelukast / zafirlukast

Q

What does Zileuton inhibit and what it is used for

A

Q

Explain Montelukast/ Zafirlukast

A

Q

What are the examples of purine

A

Adenosine
ATP
UTP
UDP

Q

Adenosine acts on what

A

In the CNS acts on metabotropic A1 receptors

Q

Purines are involved in what

A

Q

What blocks A1 receptors

A

Tea and coffee (methylxanthines)