Dose-response Relationship

Question 1

When a drug is administered systematically the dose-response relationship has what two components

Answer 1

Question 2

Generally if the dose increases what happens

Answer 2

The intensity of response increase

Question 3

What is Emax

Answer 3

The maximal response

Question 4

Define potency

Answer 4

Question 5

Define efficacy

Answer 5

Question 6

What is more important in the choice of a drug

Answer 6

Efficacy

Question 7

Why is efficacy more important than potency in the choice of drug ?

Answer 7

Question 8

What is therapeutic index

Answer 8

Question 9

What is the equation for therapeutic index

Answer 9

Question 10

Explain the therapeutic index equation

Answer 10

Question 11

What are the factors affecting dose response relationship divided into

Answer 11

Factors related to the drug
Factors related to the patient

Question 12

What are the factors related to the drug that affect dose response relationship

Answer 12

Drug shape
Time of drug administration
Drug cumulation
Drug combination

Question 13

Explain the drug shape factor

Answer 13

Question 14

Explain the time of drug administration factor

Answer 14

Question 15

Give example when time of drug administration is affecting dose response relationship

Answer 15

Question 16

Explain the drug cumulation factor

Answer 16

Question 17

Explain drug combination factor

Answer 17

When two or more drugs are combined together which can lead to:
Antagonism
Summation/addition
Synergism/ potentiation

Question 18

What is meant by summation or addition

Answer 18

Question 19

Give example of summation

Answer 19

Question 20

Explain synergism/potentiation

Answer 20

Question 21

Give example of synergism

Answer 21

Question 22

What are the factor related to the patient that affect the dose response relationship

Answer 22