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Pharmacology > Body Control Systems > Flashcards

Body Control Systems Flashcards

1
Q

Define receptor

A

Protein macromolecule
When they combine with a drug they may be activated or blocked

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2
Q

Define ligand and its types

A
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3
Q

Define affinity

A
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4
Q

What are the types of receptors

A
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5
Q

Explain ion channel linked receptor

A
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6
Q

Give examples of ion channel linked receptor

A
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7
Q

Explain G-protein-linked receptors

A
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8
Q

Give examples of G-protein-linked receptors

A
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9
Q

Explain Tyrosine enzymes kinase linked receptors

A
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10
Q

Give example of tyrosine enzyme kinase linked receptor

A

Insulin receptors

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11
Q

Where is the intracellular receptor located

A

Inside the cell either in the cytoplasm or directly on the DNA

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12
Q

Intracellular receptors are needed for what

A

They regulate transcription of genes in the nucleus or the mitochondria

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13
Q

What are the two important features of intracellular receptors

A
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14
Q

Give examples for intracellular receptors

A
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15
Q

What are the types of drug-receptor bonds

A
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16
Q

When drug combines with receptor it can lead to what

A

Agonist effect
antagonist effect
Inverse agonist
Partial agonist effect

17
Q

Explain agonist effect

A
18
Q

Explain antagonist effect

A
19
Q

Explain inverse agonist

A
20
Q

Explain partial agonist effect

A
21
Q

What are the types of antagonists

A

Competitive antagonists
Non competitive antagonists
Physiological antagonism

22
Q

Explain competitive antagonists

A
23
Q

Give example of competitive antagonists

A

Propranolol, atropine and naloxone

24
Q

Explain non-competitive antagonist

A
25
Q

Compare between reversible and irreversible antagonism

A
26
Q

What is physiological antagonism

A
27
Q

Give example of physiological antagonism

A

Adrenaline is the physiological antagonist of histamine

28
Q

Why is adrenaline the physiological antagonist of histamine

A
29
Q

How are ion channels target of drug action

A
30
Q

How drugs could modulate ion channels

A
31
Q

How drugs could affect enzymes

A
32
Q

What are D-carrier molecule

A

Small protein molecules that carry organic molecules across the cell-membrane when they are too large or too polar

33
Q

How can a drug affect the D-carrier molecule

A

By blocking their recognition site

Pharmacology (19 decks)

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