LGD-1 ANS Flashcards
What does isoproterenol do to diastolic BP? Reflex? Direct on hr? Direct on contractility? Ultimate effect on hr?
Decrease diastolic BP Reflex - vasodilation --> increase sympathetic Direct hr - up Direct contractility - up Ultimate hr -- up
What does NE do to diastolic BP? Reflex? Direct on HR? direct on contractility? Ultimate effect on HR?
Increase diastolic BP Reflex - down on sympathetic Direct hr - up Direct contractility - up Ultimate in HR - decrease , reflex dominates
What does Epi do in high conc to diastolic BP? Reflex? Direct on Hr? Direct on contractility? Ultimate Hr?
What about in low conc?
Decrease diastolic BP Reflex - down on sympathetic Direct hr - up Direct contractility - up Ultimate HR- increase
Low conc: Epi has higher affinity for b2 than a1 so preferentially effects b2 – vasodilation/ increase reflex sympathetic, decrease diastolic BP
What does phenylephrine do to diastolic BP? Reflex? Direct on HR? Direct on contractility? Ultimate HR?
Increase diastolic BP Reflex - down on sympathetic Direct hr - none Direct contractility - none Ultimate in HR - decrease
What does physostigmine do to diastolic BP? Reflex? Direct on hr?ndirec ton contractility? Ultimate HR?
diastolic BP - none Reflex - none Direct hr - decrease Direct contractility - none Ultimate in HR - decrease
What does ach do to diastolic BP? Reflex? Direct hr? Direct contractility? Ultimate hr?
Decrease diastolic BP
Reflex - vasodilation, increase sympathetic
Direct hr - decrease
Direct contractility - none
Ultimate in HR - decrease , direct dominates
What does nicotine do to diastolic BP? Reflex? Direct hr? Direct contractility? Ultimate hr?
Increase diastolic BP Reflex - down on sympathetic Direct hr - decrease Direct contractility - up Ultimate in HR - decrease
What does hexamethonium do to diastolic BP? Reflex? Direct on hr? Direct on contractility? Ultimate hr?
Decrease diastolic BP Reflex - none, blocks ganglia Direct hr - up Direct contractility - decrease Ultimate hr - increase
What does tubocurarine do to diastolic BP? Reflex? Direct hr? Direct contractility? Ultimate hr?
No change diastolic BP Reflex - no change Direct hr - no change Direct contractility - no change Ultimate in HR - no change
What does atropine do to diastolic BP? Reflex? Direct on hr? Direct on contractility? Ultimate Hr?
No effect diastolic BP Reflex - no effect Direct hr - up Direct contractility - no effect Ultimate hr - increase
Through what mech does a1 act
Ip3
Through what mech does beta act
Camp
What does DUMBBELSSS stand for?
Ps overdose D- diarrhea U- urination M- miosis B- bronchospasm B- bradycardia E- emesis L- lacrimation S- salivation S- sweating
