Lesson 4 - The Heart and Blood Flashcards
blood
connective tissue that has non-living fluid matrix that suspends living cells
plasma
the non-living fluid matrix of blood
formed elements
the living cells in blood
what percent of blood is formed elements/plasma?
45%/55%
formed elements of blood (3)
- erythrocytes
- leukocytes
- platelets
erythrocytes
red blood cells (RBC)
what do RBCs do?
transport O2
leukocytes
white blood cells (WBC)
what do leukocytes do?
they’re part of the immune system
platelets
small, colorless cell fragments in our blood that form clots and stop or prevent bleeding
plasma composition (7)
over 90% water but contains nutrients, gases, hormones, wastes, metabolites, proteins, and electrolytes
major functions of plasma components: water (2)
solvent for carrying other substances and absorbs heat
major functions of plasma components: salts (3)
include sodium, potassium, calcium, magnesium, etc.
- osmotic balance
- pH buffering
major functions of plasma components: plasma proteins
osmotic balance, clotting of blood, defense, and lipid transport
plasma proteins (3)
- albumin
- fibrinogen
- globulins
substances transported by blood: nutrients (4)
glucose, fatty acids, amino acids, vitamins
substances transported by blood: waste products (2)
urea, uric acid
substances transported by blood: respiratory gases
O2 and CO2
erythrocyte function
transport O2 and CO2
neutrophil function
phagocytize bacteria
eosinophil function (2)
kill parasitic worms; complex role in allergy and asthma
basophil function (2)
release histamine and other mediators; contain heparin and anticoagulant
lymphocyte function
mount immune response by direct attack or via antibodies
monocyte function (2)
phagocytosis; develop into macrophages in tissue
platelet function (2)
seal small tears in blood vessels; instrumental in blood clotting
What type of blood cell is this?
erythrocyte
What type of blood cell is this?
neutrophil
What type of blood cell is this?
eosinophil
What type of blood cell is this?
basophil
What type of blood cell is this?
lymphocyte
What type of blood cell is this?
monocyte
What component of blood is this?
platelets
can erythrocytes repair themselves?
no
how long do erythrocytes last in the body?
100-120 days
what cells are leukocytes produced from, and where?
hemocytoblast stem cells in bone marrow
diapedesis
the moving of leukocytes in and out of blood vessels
types of granulocytes (3)
neutrophil, eosinophil, basophil
types of agranulocytes (2)
lymphocytes and monocytes
granulocytes
cytoplasmic granules stain differentially with Wright’s stain
neutrophil (3)
most abundant WBC; active phagocyte, number increases with infection
eosinophil
attacks parasitic worms, lessens allergic reactions
basophils
contains granules with histamine causes the inflammatory response
agranulocytes/agranular leukocytes
no visible cytoplasmic granules
where are agranulocytes mainly found?
lymphatic system
lymphocyte
smallest leukocyte; functions in immunological response
B lymphocytes
produce blood antibodies
T lymphocytes
has ‘antibodies’ on the cell surface to detect and destroys grafts, tumors, and virus-infected cells
monocytes
largest leukocytes, converts into macrophages when inside tissue; engulfs foreign particles
platelets
cell fragments of megakaryocytes in bone marrow; vital role in blood clotting
coagulation
injured tissues release tissue factor TH while platelets release platelet factor PF3
what do platelet factor PF3 and tissue factor TF combine to form?
prothrombin activator
what does prothrombin activator do?
converts prothrombin in blood plasma to thrombin
what does thrombin do?
polymerizes soluble fibrinogen in plasma to insoluble fibrin which forms the clot
what forms blood clots?
fibrin
RBCs contain surface _____ which are determined by _____
antigens, genetics
type AB blood has which antigens?
antigens A and B
type B blood has which antigens?
antigen B
type A blood has which antigens?
antigen A
type O blood has which antigens?
no antigens
leukocytosis
abnormally high WBC count indicates bacterial/viral infection
leukopenia
decreased WBC count indicated typhoid fever, infectious hepatitis, cirrhosis, TB, excessive antibiotic/X-ray therapy
leukemia
uncontrolled proliferation of WBC and reduction of RBC and platelets
polycythemia
increased RBC count from living in high altitudes or bone marrow cancer
anemia
decreased RBC count
anemia: iron deficiency
caused by lack of iron
anemia: sickle cell
RBC have abnormal shape causing decreased O2 carrying ability
anemia: aplastic
bone marrow produces too few RBCs
anemia: pernicious
reduced RBC production due to lack of vitamin B12
RBC production is influenced by what hormone?
erythropoietin
erythropoietin
hormone from the kidneys that stimulate RBC production in bone marrow
hematocrit
the percent of blood volume occupied by RBCs
PCV: packed cell volumes
used to detect anemia
high PCV to hemoglobin ratio indicates what?
anemia