Lecture7: Glucoroticoid Disorders

Question 1

Which syndrome leads to hyper secretion of glucocorticoids?

Answer 1

Cushing syndrome

Question 2

Which syndrome leads to Hyposecretion of glucocorticoids?

Answer 2

Addison’s disease

Question 3

If the cause of Cushing syndrome was Hypothalmic, what there be a notable decrease of?

Answer 3

Both CRF and ACTH

Question 4

if the cause of Cushing was Pituitary, what would there be a notable increase of?

Answer 4

ACTH only

Question 5

Effects of hypersecretion of glucocorticoids?

Answer 5

Muscle wasting, thin skin, delayed wound healing

Question 6

Characteristic sign of hypersecretion?

Answer 6

Abdominal Striae

Question 7

How do we identify Cushing from the face?

Answer 7

Acne, salt and water retention, and fat mobilization

Question 8

What is the cause of abdominal striae?

Answer 8

The rupture of subdermal capillaries

Question 9

Effects of Hyposecretion?

Answer 9

Anemia and Hypoglycemia

Question 10

Melanin pigmentation is a sign of Hyposecretion, what causes it?

Answer 10

The increased secretion of ACTH resultant from loss of negative feedback mechanism

Question 11

What are sites of melanin pigmentation?

Answer 11

Skin, scars and mucous

Question 12

What are Adrenal Androgens responsible for?

Answer 12

The development of sex and mascunalizing shite

Question 13

Hypersecretion of Adrenal Androgens in females is called?

Answer 13

Virilism

Question 14

What is Congenital Adrenal Hyperplasia (CAH) ?

Answer 14

When there’s a gene mutation of CYP21

Question 15

What happens in CAH?

Answer 15

Adrenal androgens increase, and both glucocorticoids and mineralcorticoids decrease