Lecture35: Diabetes Mellitus 2

Question 1

What increases rate of AGE formation?

Answer 1

Hyperglycemia

Question 2

What receptor do AGE’s bind to?

Answer 2

RAGE

Question 3

Are AGE’s implicated in diabetic retinopathy?

Answer 3

Yes

Question 4

AGE effect on vascular smooth muscle?

Answer 4

Increased proliferation and synthesis of extracellular matrix