Lecture 34: Diabetes Mellitus 1 Flashcards
What causes Type 1 diabetes?
Absolute deficiency of insulin caused by autoimmune attack on islet B cells of the pancreas
What might result from Type 1?
Insulitis
Which diabetes type had strong genetic influence?
Type 2
What is the most common type of diabetes?
Type 2
What’s an acute complication of Type 1?
Ketoacidosis
Which cycle stimulates anabolism?
Feed cycle
What is the first organ to respond to the influx of nutrients after a meal?
Liver
What follows the feed cycle, so long as the person is non-diabetic?
Fed state
Hyperglycemia is resultant from diabetes, why?
Glucose production increases, and GLUT4 receptors decrease the glucose uptake
Ketonemia results from?
Excessive mobilization of fatty acids
How are ketone bodies formed from ketonemia?
Beta oxidation of fatty acids releases Acetyl CoA
Ketonemia is particularly present in Type…?
1
Why is Ketonemia more characteristic of type 1, not 2?
Insulin is present in two, and that inhibits ketogenesis
Signs of diabetes?
Blurry vision, yeast infections
How is Diabetic Ketoacidosis treated?
Via Fluid and Electrolyte replacement, coupled with admin of short acting insulin
Non-ketoacidotic comas (DKA) are most common in which type of DM?
Type 2
Hyperglycemic coma’s are most common in which type?
Type 1
What is Gestational Diabetes?
Pregnant woman experiences onset of DM for the first time during pregnancy
Symptoms of LADA are the same as which DM type?
Type 2
What age group do we diagnose lada?
30 years
Insulin resistance alone doesn’t lead to type 2 DM, what else does it need?
Impaired B cell function
The symptom of insulin resistance is?
Acanthosis nagricans, dark patches around skin fold areas
