Lecture Exam 2 - Chapter 6 Flashcards
Which is a function of the skeletal system?
(a) support, (b) hematopoietic site, (c) storage, (d) providing levers for muscle activity, (e) all of these.
(e) all of these
A bone with approximately the same width, length, and height is most likely
(a) a long bone, (b) a short bone, (c) a at bone,
(d) an irregular bone.
(b) a short bone
The shaft of a long bone is properly called the
(a) epiphysis, (b) periosteum, (c) diaphysis, (d) compact bone.
(c) diaphysis
An osteon has
(a) a central canal carrying blood vessels,
(b) concentric lamellae, (c) osteocytes in lacunae, (d) canaliculi that connect lacunae to the central canal, (e) all of these.
(e) all of these
The remodeling of bone is a function of which cells?
(a) chondrocytes and osteocytes, (b) osteoblasts and osteoclasts, (c) chondroblasts and osteoclasts, (d) osteoblasts and osteocytes.
(b) osteoblasts and osteoclasts
Formation of the bony callus in fracture repair is followed by
(a) hematoma formation, (b) brocartilaginous callus formation, (c) bone remodeling, (d) formation of granulation tissue.
(c) bone remodeling
The fracture type in which the bone ends are incompletely separated is
(a) greenstick, (b) compound, (c) simple,
(d) comminuted, (e) compression.
(a) greenstick
_________ bones – longer than they are wide
Long
_________ bones – small and boxy; length and width close to equal
Short
_________ bones – have thin parallel surfaces
Flat
_________ bones – complex shapes
Irregular
_________ bones – small and flat; develop inside tendons
Sesamoid
-Type of Bone-
_________: humerus, ulna, radius, and femur
Long
-Type of Bone-
Carpal bones of the wrist and tarsal bones of the ankle
Short
-Type of Bone-
Cranial bones, ribs, and sternum
Flat
_________ bones – flat bones found in the suture lines of the skull
Sutural (Wormian)
-Type of Bone-
Vertebrae, bones of the pelvis
Irregular
-Type of Bone-
Patella (kneecap), also commonly found in the hands, feet, and knees
Sesamoid -
-Functions of Bones-
_________ – provides structural support for the entire body
Support
-Functions of Bones-
_________ - Surround soft tissue – ribs and sternum protect the heart and lungs, skull protects the brain
Protection
-Functions of Bones-
_________ – skeletal muscle is attached to bone so it pulls on the bone when it contracts
Movement
-Functions of Bones-
_________ – stores calcium and phosphorus
-Minerals are released into the blood when need
Mineral homeostasis
-Functions of Bones-
_________ - Red bone marrow produces red blood cells, white blood cells and other blood elements
Blood cell production
-Functions of Bones-
_________ - Yellow marrow stores fat
Storage of lipids
-Functions of Bones-
_________ – produce osteocalcin
-Hormone involved in insulin secretion and glucose balance
Hormone production
-Functions of Bones-
-Support - -Movement - -Blood cell production -Storage of lipids -Hormone production
- Protection
- Mineral homeostasis
-Functions of Bones-
-Support
-Protection
-
-Mineral homeostasis
-Blood cell production
-
-Hormone production
- Movement
- Storage of lipids
-Functions of Bones-
-Support
-Protection
-Movement
-Mineral homeostasis
-
-Storage of lipids
-
- Blood cell production
- Hormone production
- Long Bones -
_________ – shaft of the bone
Diaphysis
- Long Bones -
Diaphysis – shaft of the bone
-Thick layer of _________ bone that surrounds the _________ cavity
- compact
- marrow
- Long Bones -
_________ – end of the bone
Epiphysis
- Long Bones -
Epiphysis – end of the bone
a. Usually wider than the _________
b. Made up of _________ (or cancellous) bone
c. Ends are covered with hyaline cartilage
d. Epiphyseal plate – growth plate
- diaphysis
- spongy
- Long Bones -
Epiphysis – end of the bone
a. Usually wider than the diaphysis
b. Made up of spongy (or cancellous) bone
c. Ends are covered with _________ cartilage
d. Epiphyseal plate – _________ plate
- hyaline
- growth
- Long Bones -
_________ – hyaline cartilage that covers the end of a bone
Articular cartilage
- Long Bones -
_________ – dense irregular connective tissue that encloses bone
Periosteum
- Long Bones -
_________ – space in the middle of the bone
Medullary (marrow) cavity
- Long Bones -
_________ – membrane that lines the inside of the medullary cavity
Endosteum
Chemical composition of _________ :
- ½ hydroxyapatite
- ¼ collagen
- ¼ water
bone matrix
Chemical composition of bone matrix:
- ½ _________
- ¼ collagen
- ¼ _________
- hydroxyapatite
- water
Chemical composition of bone matrix:
- __ hydroxyapatite
- __ collagen
- __ water
- ½
- ¼
- ¼
_________ - Makes bone very hard to resist compression
-Also very brittle and inflexible
hydroxyapatite
_________ - Helps resist tension (pulling)
-Gives bone some flexibility
collagen
_________ – shock absorption
water
-Cells found in Bone-
_________ – stem cells that develop into osteoblasts
Osteogenic cells
-Cells found in Bone-
_________ – immature bone cells
Osteoblasts
-Cells found in Bone-
_________ – mature bone cells; found inside a lacuna
Osteocytes
-Cells found in Bone-
_________ – cells that break down and remove bone
Osteoclasts
-Cells found in Bone-
Osteogenic cells - Found on the inside of the _________ and endosteum and in canals that contain _________
- periosteum
- blood vessels
-Cells found in Bone-
Osteoblasts - Make and secrete _________ fibers and ingredients of _________
- collagen
- matrix
-Cells found in Bone-
Osteocytes - Maintain the bone _________
-Repair damaged _________
- matrix
- bone
-Cells found in Bone-
Osteoclasts - Helps to maintain the _________ and phosphate levels in the _________
- calcium
- blood
-Cells found in Bone-
_________ - Found on the inside of the periosteum and endosteum and in canals that contain blood vessels
Osteogenic cells
-Cells found in Bone-
_________ - Make and secrete collagen fibers and ingredients of matrix
Osteoblasts
-Cells found in Bone-
_________ - Maintain the bone matrix
-Repair damaged bone
Osteocytes
-Cells found in Bone-
_________ - Helps to maintain the calcium and phosphate levels in the blood
Osteoclasts
_________ – membrane that covers every bone
Periosteum
Functions of the Periosteum:
- _________ from surrounding tissues
- Provides route for _________ and nerves
- Helps in bone growth and repair
- Isolates bone
- blood vessels
Functions of the Periosteum:
- Isolates bone from surrounding tissues
- _________ for blood vessels and nerves
- Helps in bone _________ and _________
- Provides route
- growth
- repair
Functions of the _________ :
- Isolates bone from surrounding tissues
- Provides route for blood vessels and nerves
- Helps in bone growth and repair
Periosteum
_________ – collagen fibers from tendons, ligaments, and periosteum that attach them to the bone
Sharpey’s fibers
Sharpey’s fibers – collagen fibers from tendons, ligaments, and _________ that _________ them to the _________
- periosteum
- attach
- bone
_________ – functional unit of compact bone; each one looks like a cross section of a tree
Osteon
- Osteon -
_________ – middle of the osteon
- Contain blood vessels, nerve, and a lymphatic vessel
- Run parallel to the surface of the bone
Central (or Haversian) canals
- Osteon -
Central (or Haversian) canals – middle of the osteon
- Contain _________, nerve, and a _________ vessel
- Run parallel to the surface of the bone
- blood vessels
- lymphatic
- Osteon -
_________ – travel perpendicular to the central canals
Perforating (or Volkmann’s) canals
- Osteon -
Perforating (or Volkmann’s) canals - Provide _________ to the osteons and _________ tissue
- blood
- bone marrow
- Osteon -
_________ – layers of matrix
Lamellae
- Osteon -
Lamellae – Contains _________ fibers that run at angles to add _________ and resilience
- collagen
- strength
- Osteon -
_________ – “little lakes” – spaces in between lamellae that contain osteocytes
Lacunae
- Osteon -
Lacunae – “little lakes” – spaces in between _________ that contain _________
- lamellae
- osteocytes
- Osteon -
_________ – “small channels” – canals that connect lacunae with one another and the Haversian canal
Canaliculi
- Osteon -
Canaliculi – “small channels” – canals that connect _________ with one another and the _________ canal
- lacunae
- Haversian
_________ :
- No osteons
- Matrix is arranged in trabeculae – thin columns of bone that form a network
- Found in areas of lower stress
- Can resist forces from many directions
- Much lighter than compact bone – reduces the weight of the skeleton
- Contains red bone marrow – red blood cell formation
-Spongy Bone Structure-
-Spongy Bone Structure-
- No osteons
- Matrix is arranged in _________ – thin columns of _________ that form a network
- Found in areas of lower stress
- Can resist forces from many directions
- Much lighter than compact bone – reduces the weight of the skeleton
- Contains red bone marrow – red blood cell formation
- trabeculae
- bone
-Spongy Bone Structure-
- No osteons
- Matrix is arranged in trabeculae – thin columns of bone that form a network
- Found in areas of lower _________
- Can resist _________ from many directions
- Much _________ than compact bone – reduces the weight of the skeleton
- Contains red bone marrow – red blood cell formation
- stress
- forces
- lighter
-Spongy Bone Structure-
- No osteons
- Matrix is arranged in trabeculae – thin columns of bone that form a network
- Found in areas of lower stress
- Can resist forces from many directions
- Much lighter than compact bone – reduces the _________ of the skeleton
- Contains _________ bone marrow – red blood cell _________
- weight
- red
- formation
_________ – thin columns of bone that form a network
trabeculae
-Three sets of vessels in a long bone-
_________ – main artery and vein that invade during development
Nutrient artery and vein
-Three sets of vessels in a long bone-
_________ – provide blood supply to the developing bone at the epiphyseal cartilage
Epiphyseal vessels
-Three sets of vessels in a long bone-
_________ – provide blood to the superficial osteons
Periosteal blood vessels
_________ in a long bone-
- Nutrient artery and vein
- Epiphyseal vessels
- Periosteal blood vessels
-Three sets of vessels
Four steps of Intramembranous Ossification:
- Calcification
- Formation of trabeculae
- Development of periosteum
Development of center of ossification
Four steps of Intramembranous Ossification:
-Formation of trabeculae
-Development of periosteum
Calcification
Four steps of Intramembranous Ossification:
-Development of center of ossification
-Calcification
-
-Development of periosteum
Formation of trabeculae
Four steps of Intramembranous Ossification:
-Development of center of ossification
-Calcification
-Formation of trabeculae
-
Development of periosteum
Five steps of Endochondral ossification:
-
- Growth of cartilage model
- Periosteal bud invades
- Medullary cavity
- Secondary ossification centers
Bone collar forms around diaphysis
Five steps of Endochondral ossification:
-Bone collar forms around diaphysis - -Periosteal bud invades -Medullary cavity -Secondary ossification centers
Growth of cartilage model
Five steps of Endochondral ossification:
-Bone collar forms around diaphysis
-Growth of cartilage model
-
-Medullary cavity
-Secondary ossification centers
Periosteal bud invades
Five steps of Endochondral ossification:
- Bone collar forms around diaphysis
- Growth of cartilage model
- Periosteal bud invades
- Secondary ossification centers
Medullary cavity
Five steps of Endochondral ossification:
-Bone collar forms around diaphysis
-Growth of cartilage model
-Periosteal bud invades
-Medullary cavity
-
Secondary ossification centers
_________ – increase in the diameter of the bone
Appositional growth
Appositional growth:
- Osteoblasts near the _________ secrete matrix
- Osteoblasts are surrounded and become _________
- Osteoclasts destroy bone inside the medullary cavity, increasing the diameter
- periosteum
- osteocytes
Appositional growth:
- Osteoblasts near the periosteum secrete matrix
- Osteoblasts are surrounded and become osteocytes
- _________ destroy bone inside the _________ cavity, increasing the diameter
- Osteoclasts
- medullary
About __% of the spongy bone is replaced each year
20
-Exercise-
If a muscle pulls on a bone repetitively or with a lot of force, that area of bone where the muscle attaches will need more strength
More bone will be _________ to reinforce the area
deposited
_________ – hormone made by the kidneys
- Needed for absorption of calcium and phosphate
- Dependent on Vitamin D
Calcitrol
Calcitrol - hormone made by the kidneys
- Needed for absorption of _________ and phosphate
- Dependent on Vitamin __
- calcium
- D
Vitamin __ – needed for collagen synthesis and osteoblasts differentiation
C
Vitamins A, K, and B12 – needed to make _________
proteins
_________ - Important to the membranes and intracellular activities of neurons and muscle cells
Calcium
Blood Calcium levels:
Increase of __% causes muscles and neurons to become _________
- 30
- unresponsive
Blood Calcium levels:
Decrease of __% can cause _________
- 35
- convulsions
Blood Calcium levels:
Decrease of __% causes _________
- 50
- death
_________ and parathyroid hormone (___)
Coordinate Hormone storage, absorption, and excretion
- calcitonin
- PTH
PTH raises blood calcium levels in one of three ways:
- Stimulate the _________ to remove some bone to release _________ into the blood
- Stimulates the digestive tract to increase the rate of calcium absorption
- Decreases the rate of excretion from the kidneys
- osteoclasts
- calcium
PTH raises blood calcium levels in one of three ways:
- Stimulate the osteoclasts to remove some bone to release calcium into the blood
- Stimulates the _________ tract to increase the rate of _________ absorption
- Decreases the rate of excretion from the kidneys
- digestive
- calcium
PTH raises blood calcium levels in one of three ways:
- Stimulate the osteoclasts to remove some bone to release calcium into the blood
- Stimulates the digestive tract to increase the rate of calcium absorption
- Decreases the rate of _________ from the _________
- excretion
- kidneys
Calcitonin – decreases blood calcium levels in one of two ways:
- Inhibits _________
- Increases rate of _________ from the _________
- osteoclasts
- excretion
- kidneys
Fractures – 4 ways to classify a break:
-
- Completeness of break
- Orientation of break to the long axis
- Penetration of the skin
Position of bones
Fractures – 4 ways to classify a break:
-Orientation of break to the long axis
-Penetration of the skin
Completeness of break
Fractures – 4 ways to classify a break:
-Position of bones
-Completeness of break
-
-Penetration of the skin
Orientation of break to the long axis
Fractures – 4 ways to classify a break:
-Position of bones
-Completeness of break
-Orientation of break to the long axis
-
Penetration of the skin
- Types of Fractures -
_________ – bone is broken into 3 or more pieces
Comminuted
- Types of Fractures -
_________ – bone is crushed; common in vertebrae
Compression
- Types of Fractures -
_________ – usually occurs with twisting of the bone
Spiral fracture
- Types of Fractures -
_________ – diaphysis and epiphysis separate
Epiphyseal fracture
- Types of Fractures -
_________ – part of skull is pushed in
Depression fracture
- Types of Fractures -
_________ – incomplete fracture; occurs in children
Greenstick fracture
- Types of Fractures -
_________ – occurs when a tendon pulls part of the bone away
Avulsion fracture
4 steps of Fracture repair:
_________ – clump of clotted blood from breaking blood vessels around the break site; becomes swollen and hurts
Hematoma
4 steps of Fracture repair:
_________ -
- Phagocytes come in to clean up the mess
- Fibroblasts, chondroblasts, and osteoblasts start forming new collagen, cartilage, and bone
Fibrocartilaginous callus forms
4 steps of Fracture repair:
_________ -
-New trabeculae begin to show up and the fibrocartilaginous callus is converted to bone
Bony callus forms:
4 steps of Fracture repair:
_________ – Bony callus is reformed and refined until the bone looks similar to the way it did before the fracture. However, it is often possible to tell on X-ray and sometimes by palpation where a break occurred
Bone remodeling
4 steps of Fracture repair:
-
-Fibrocartilaginous callus forms
-
-Bone remodeling
- Hematoma
- Bony callus forms
4 steps of Fracture repair:
-Bony callus forms
-
- Fibrocartilaginous callus forms
- Bone remodeling
-Bone Conditions-
_________ – lack of vitamin D; causes bones to be too soft; legs are bowed
Rickets
-Bone Conditions-
Rickets – lack of vitamin __; causes bones to be too _________ ; legs are bowed
- D
- soft
-Bone Conditions-
_________ – bone resorption happens faster than bone deposit
Osteoporosis
-Bone Conditions-
Osteoporosis –
- Caused by _________ changes, lack of _________, lack of exercise, and smoking
- Can lead to compression _________ in the vertebrae, or a broken hip
- hormonal
- calcium
- fractures
-Bone Conditions-
_________ – osteoblasts and osteoclasts are hyperactive
Paget’s Disease
-Bone Conditions-
Paget’s Disease –
i. Not enough compact _________ is formed
ii. Reduced _________
iii. Causes weakening of bones, but they become larger and more rugged
iv. Cause is unknown, but a virus may bring it on
- bone
- mineralization
-Bone Conditions-
Paget’s Disease –
i. Not enough compact bone is formed
ii. Reduced mineralization
iii. Causes _________ of bones, but they become _________ and more rugged
iv. Cause is unknown, but a _________ may bring it on
- weakening
- larger
- virus
-Bone Conditions-
_________ – condition of the lungs – caused by a bacterial infection
Tuberculosis
-Bone Conditions-
Tuberculosis -
If it gets to the _________, it can cause compression fractures in the _________ .
- skeleton
- vertebrae
-Bone Conditions-
_________ – is inflammation of bone
Osteomyelitis
-Bone Conditions-
Osteomyelitis -
i. Caused by _________ that usually gets in through a wound
ii. Causes _________ of bone and lots of pus is formed
iii. Can be _________
- bacteria
- swelling
- fatal
-Bone Conditions-
_________ – immobility in a joint
Ankylosing Spondylitis
-Bone Conditions-
Ankylosing Spondylitis –
i. Usually affects the _________
ii. Ligaments around the spine _________, so intervertebral joints become _________
- spinal column
- ossify
- immobile