Lecture exam 2 (Aerobic metabolism) Flashcards

1
Q

pyruvate enters the mitochondria of the cell for this

A

aerobic metabolism

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2
Q

aerobic demands are less than

A

80% max intensity

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3
Q

T/F: body perfers aerobic oxidative metabolism

A

T

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4
Q

This must be in sufficient concentration to have pyruvate enter the mitochondria

A

O2

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5
Q

during aerobic metabolism you use this to produce this

A

O2

CO2

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6
Q

acetic acid is an example of a

A

2 carbon acid

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7
Q

acetyl-CoA =

A

acetic acid + coenzyme A

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8
Q

484-884 rule

A

when we calculate ATP production we assum all pyruvate is coverted to acetyl CoA and none goes to oxaloacetate (directly)

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9
Q

These are the intermediate steps between glycolysis and kerbs cycle

A

PDH

PC

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10
Q

This always proceeds aerobic metabolism

A

anaerobic metabolism

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11
Q

T/F: aerobic metabolism occurs inside the sarcoplasm

A

F, mitochondria

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12
Q

Kreb’s cycle goes from here to here

A

citrate to citrate

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13
Q

2 other names for kreb’s cycle

A

citric acid cycle

tricarboxylic acid cycle

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14
Q

aerobic pathways is only used in presence of this

A

O2

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15
Q

Citrate is formed by the combination of these to intermediates by this enzyme

A

Acetyl-CoA
Oxaloacetate
Citrate synthase

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16
Q

Citrate has this many carbons

A

6

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17
Q

After citrate is reacted with aconatase this is prduced

A

isocitrate

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18
Q

isocitrate is converted to this by this enzyme

A
alpha-ketogluterate
isocitrate dehydrogenase (IDH)
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19
Q

This is the rate limiting enzyme of krebs cycle

A

isocitrate dehydrogenase (IDH)

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20
Q

AKG has this many carbons

A

5

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21
Q

What happens during the IDH step other than conversion

A

NAD is reduced to NADH+H+

CO2 is released

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22
Q

This enzyme has the lowest turnover ratio in krebs cycle

A

IDH

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23
Q

Alpha-ketogluterate is converted to this by this

A

succinyl coenzyme A

alpha-ketogluterate dehydrogenase

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24
Q

succinyl coA has this man carbons

A

4

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25
what happens during the AKGDH step other than coversion
NAD is reduced to NADH+H+ | CO2 is released
26
Succinyl CoA is converted to this by this
succinate | succinyl coenzyme A synthetase
27
what happens during the succinyl coenzyme A synthetase step other than conversion
1 ATP is produced
28
Succinate is converted to this by this
``` fumerate succinate dehydrogenase (SDH) ```
29
What is a functional use for SDH concentration
Muscle typing, oxidative muscles have more
30
what happens during the SDH step other than conversion
FAD is reduced to FADH2
31
fumerate is converted to this by this
``` malate unnamed enzyme (don't need to know) ```
32
malate is converted to this by this
``` oxaloacetate malate dehydrogenase (MDH) ```
33
what happens durin the MDH step other than conversion
NAD is reduced to NADH+H+
34
These are all the 4 carbon compounds in krebs
Malate Fumerate Succinate succinyl CoA
35
From glycolysis to the end of krebs cycle 1 molecule of blood glucose will net
4 ATP 10 NADH+H+ 2 FADH2
36
From pyruvate two end of krebs cycle will net
1 ATP 4 NADH+H+ 1 FADH2
37
From acetyl-CoA to end of krebs cycle will net
1 ATP 3 NADH+H+ 1 FADH2
38
T/F: electron transport system is anaerobic
F, aerobic
39
the ETS is this type of phosporylation
oxidative
40
This is another way to describe the electron transport chain
hydrogen transport system
41
The passage of electrons/hydrogen are all examples of this type of reaction
oxidation reduction
42
ETS: First electron acceptor
flavoprotein
43
flavoprotein is made by this substance
Vit. B2 or riboflavin
44
NADH+H+ enters the ETS at this stage
flavoprotein
45
Flavoprotein reduces
Coenzyme Q
46
FADH2 enters the ETS at this stage
Coenzyme Q
47
Coenzyme Q is a derivative of
Vit E
48
Coenzyme Q reduces
cytochrome b
49
cytochrome b reduces
cytochrome C
50
Cytochrome C reduces
cytochrome a
51
cytochrome a reduces
cytochrome asub3
52
1/2 O2 is reduced to H2O at the end of this step
cytochrome a to cytocrome asub3
53
ATP is produced at these steps of the ETS
flavoprotein to coenzyme Q cytochrome b to cytochrome c cytochrome a to cytochrome asub3
54
Theoretical yield model of the ETS is
3 ATP from the whole system
55
Oxidation of NADH+H+ in the ETS generates this much ATP
3
56
Oxidation of FADH2 in the ETS generates this much ATP
2
57
These are iron containing molecules similar to hemo/myo-globin
cytochromes
58
Oxygen is called this
the final election acceptor
59
the more oxygen consumed increases this
ATP production over time
60
Each molecule of blood glucose converted to CO2 and H2O produces a net of this much ATP
38 ATP
61
4 feedback systems associated with carb metabolism
pasteur effect high concentrations of ATP inhibit citrate synthase end of exercise high concentrations of ATP inhibits G3PDH LDH, PK, PFK are inhibitied by increase in ATP concentraion
62
kreb's cycle processes are inhibited by a lack of oxidated NAD, that causes the cellular concentrations of ATP to go down with a concomitant increase in cellular concentration of ADP. And ADP stimulates PFK
Pasteur effect
63
This is a stop gap procedure
pasteur effect
64
define stop gap procedure
doesn't cure, but help us get through (delay) effects of a problem
65
Pasteur effect is initiated when this occurs
ETS is backing up not allowing NADH+H+ to be oxidized
66
As a result of the pasteur effect this increases, and causes this
anaerobic ATP production | fatigue through accumulation of lactate
67
% intensity that can be ran at without fatiguing due to accumulation of lactate, or without running out of oxygen to use as final electron acceptor (approx 80% max)
anaerobic threshold
68
What do we need to do at the end of exercise
store intermediates as carbs so they can be used in the future
69
When high concentrations of ATP that inhibit citrate synthase occur our bodies do this
store acetic acid as fat
70
When citrate synthase is inhibited due to high concentrations of ATP we start to back up at this step, resulting in this
PDH | acetic acid builds up in the mitochondrea
71
1 cycle of the krebs cycle produces this much ATP
12
72
Acetic acid being stored as fats explain this
how carbohydrates that we eat are stored as fat (one mechanism)
73
At the end of exercise high concentrations of ATP inhibit G3PDH resulting in this
G3P and DHAP build up in the cell and are eventually stored as fats
74
LDH, PK, PFK are inhibited by increased ATP concentrations which then favors the production of this
glycogen from glucose
75
Fatty-acits are utilized through this type of metabolism
aerobic
76
aerobic metabolism of fatty acids is know as
beta oxidation of fatty acids
77
This provides very little ATP per unit time
Beta oxidation of fatty acids
78
One benefit of beta-oxidation of fatty acids
inexhaustable storage capacity of fat
79
R-value associated with beta-oxidation of fatty acids
0.7
80
FA are stored in this form
triglycerides
81
triglyceride =
glycerol backbone = 3 FA
82
This breaks down triglycerides to its constituents
lipase
83
fatty acids are
long carbon (mostly even #) chains
84
N =
of carbons in a fatty acid chain
85
energy cost to prepare one FA for Beta-oxidation
1 ATP to AMP +P2
86
First reduction agent formed from BO
1 FADH2
87
Second reduction agent formed from BO
1 NADH+H+
88
Final substance fromed from BO
1 acetyl-CoA
89
ATP does not get used here in BO of FA
to add CoA to the carbon chain in the cycle
90
Each cycle cleaves this many carbons form the fatty acid
2
91
When determining the amount of ATP produced from burning a FA know these 2 things
``` # of cycles # of acetyl-CoA produced ```
92
of cycles of BO of FA =
(N/2)-1
93
Each cycle of BO of FA produces this much ATP from production of reduction agents
5 ATP
94
of acetyl-CoA produced in BO of FA =
(N/2)
95
Each acetyl-CoA produced during BO of FA produces this much ATP when burned to CO2 and H2O
12
96
Enter net and gross equations into calculator for BO of FA
okay