Lecture 9 Flashcards
Consists of the skin and its accessory structures including the hair, nails, and glands
Integumentary System
Exterior covering of the body
Skin
Weight of skin
6 pounds in the average adult
Coverage of skin
More than 3000 square inches
Largest organ of the body
Skin
Skin is supplied with
Blood vessels
Nerves
Functions of the skin
Protection Prevents dehydration Regulates body temp Provides sensation Blood reservoir Excretion
Three major regions of the skin
Epidermis
Dermis
Hypodermis
Outermost superficial region
Epidermis
Middle region
Dermis
Superficial fascia
Deepest region
Hypodermis
Composed of keratinized stratified squamous epithelium, consisting of four distinct cell types and four or five layers
Epidermis
Cell types include
Keratinocytes
Melanocytes
Merkel cells
Langerhan’s cells
Function of the epidermis
Protection from external environment
Produce the fibrous protein keratin
Keratinocytes
Produce the brown pigment melanin
Melanocytes
Epidermal macrophages that help activate the immune system
Langerhan’s cells
Function as touch receptors in association with sensory nerve endings
Merkel cells
Layers of the epithelium
Stratum corneum
Stratum granulosum
Stratum spinosum
Stratum basale
Outermost layer of keratinized cells
Accounts for three quarters of the epidermal thickness
Stratum Corneum
Another name for stratum corneum
Horny Layer
Functions of the stratum corneum:
Waterproofing Protection Rendering the body insensitive 20-30 cell layers thick 40lbs shed in a lifetime Too far from blood vessels
Between stratum granulosum and corneum
Consists of a few rows of flat, dead keratonicytes or are in the process of dying
Stratum Lucidum
Another name for stratum lucidum
Clear layer
Stratum lucidum is present on in thick skin such as:
Palms of hands
Fingertips
Soles of feet
Thin, 3-5 cell layers in which drastic changes in keratinocyte appearance occurs
Stratum granulosum
Another name for stratum granulosum
Granular layer
Produce keratin and squamous cells flatten as they are pushed upward
Keratinocytes
Accumulate in the cells of the stratum granulosum
Keratohyaline
Lamellated granules
Cells contain weblike system of intermediate filaments attached to desmosomes
Keratinocytes shrink but desmosomes hold in place
Stratum spinosum
Another name for stratum spinosum
Prickly layer
Cells abundant in th stratum spinosum
Melanin granules
Langerhan’s cells
Deepest epidermal layer firmly attached to the dermis
Consists of a single row of the youngest keratinocytes
Stratum Basale
Another name for stratum basale
Basal layer
Alternate name from stratum basale because cells undergo rapid division
Stratum germinativum
Cells found in stratum basale
Melanin
Beneath the epidermis and is composed of connective tissue
Dermis
The dermis contains
Lymphatics Nerves Nerve endings Blood vessels Sebaceous glands Sweat glands Elastic fibers Hair follicles
Cell types of the dermis
Fibroblasts
Macrophages
Mast cells
White blood cells
Role of dermis
Temperature regulation
Two layers of the dermis
Papillary
Reticular
Arranged into microscopic structures that form ridges
These are the finger and footprints
Papillary layer
Beneath the papillary layer
It is a white fibrous tissue that supports the blood vessels
Reticular Layer
Superior surface of the papillary layer that contains peglike projections called
Dermal papillae
Dermal papillae contain
Capillary loops
Meissner’s corpuscles
Free nerve endings
Reticular layer accounts for
80% of the skin thickness
Add strength and resiliency to the skin
Collagen fibers
Provide stretch-recoil properties
Elastin fibers
Composed of adipose and connective tissue
Supports, nourishes, insulates, and cushions the skin
Subcutaneous tissue
or hypodermis
Another name for hypodermis
Superficial fascia
Three pigments that contribute to skin color
Melanin
Carotene
Hemoglobin
Yellow to reddish-brown to black pigment, responsible for dark skin colors
Melanin
Result from local accumulations of melanin
Freckles
Pigmented moles
Yellow to orange pigment, most obvious in the palms and soles of the feet
Carotene
Reddish pigment responsible for the pinkish hue of the skin
Hemoglobin
The only pigment produced in the skin
Melanin
Greek for black
Melan
1 M1M1M2M2
Black Skin
2 M1M1M2m2
Dark Brown Skin
3 M1M1m2m2
Brown Skin
4 M1m1m2m2
Light Brown Skin
5 m1m1m2m2
White Skin
Pigments which affects skin color
Cyanosis Erythema Pallor or blanching Jaundice Bronzing Hematoma
Bluish hue to the skin due to heart failure or respiratory disease
Cyanosis
Reddish hue to the skin due to blushing, fever, hypertension, polycythemia
Erythema
Pale skin hue due to emotional stress (fear, anger), anemia, or hypotension
Pallor or blanching
Yellow hue to the skin due to liver disorder
Jaundice
Skin condition due to Addison’s disease (adrenal cortex of the kidney hypofunctions)
Bronzing of the skin
Bruises
Blood leaks out of capillaries due to trauma and clots under the skin
Hematoma
Derieved from epidermis but extend into dermis
Skin appendages
Skin appendages include
Hair and hair follicles
Sebaceous glands
Sweat glands
Nails
Of hard keratin
Corresponds to hooves and claws
Grows from nail matrix
Nails
Begins several millimeters into the finger and extends the edge of the white, crescent-shaped lunula
Nail root
aka germinal bed or nailbed
Growth of nail occurs
Approximately 1mm per week
The under-surface of the nail plate has
Grooves that help ancher it
Cuticle of the nail
Eponychium
Fuses the nail plate and the skin of the finger together to form a waterproof barrier
Eponychium
Under the free edge of the nail
Creates waterproof barrier, fusing the skin of the finger to the underside of the nail plate
Hyponychium
Simply those that have curled down or around and are growing into the skin
Become swollen and inflamed
Ingrown nails
Derived from epidermis and dermis
Everywhere but palms, soles, nipples, parts of genitalia
Hair and hair follicles
Threadlike structure formed by a group of cells that develop within a hair follicle or socket
Hair
Muscle attached to the side of each follicle
Stimulated by skin irritants, emotional arousal, or cold temperatures, and reacts by contracting
Causes goose flesh or pimples
Pilomotor
Bulb enclosing a loop of capillaries
Provide nourishment to the hair
Responsible for hair growth
Hair papilla
Cover the hair shaft like shingles on a roof, protecting it from the elements and chemicals, and from losing moisture
Transparent cuticle
Provides most of the hair’s weight
Contains melanin
When cuticle is destroyed and this is exposed, hair looks dull and dry
Cortex
Inner hollow core that runs the length of the shaft
Medulla
Parts of the hair
Roots
Shaft
Make up of hair
Hard keratin
Three concentric layers of the hair
Medulla
Cortex
Cuticle
Functions of the hair
Detect insects before they bite Prevents heat loss UV protection Protects against trauma Hair appearance
Types or hair
Vellus (shorter)
Intermediate hair
Terminal (longer, courser)
Hair growth (2mm/week)
Active
Resting phase
Controlled
Thinning - age related Pattern baldness (alopecia)
Hair Loss
Hair color influence by:
Melanin
Hormones
Environment
Two kinds of melanin
Eumelanin
Pheomelanin
Colors hair brown to black
Has an iron-rich pigment
Eumelanin
Colors it yellow-blonde to red
Pheomelanin
Oil glands
Have tiny ducts that open into each hair follicle
Sebaceous glands
Sebaceous glands secretes
Sebum
Function of sebum
Lubricates hair and skin
The amount of secretion varies with
Age
Puberty
Pregnancy
Occurs when duct is blocked by accumulated sebum and staphylococcus infection begins
Whitehead
When whitehead is oxidized and dries out
Blackhead
Sweat glands
About 2 million are distributed over the surface of the body, more numerous on the palm of the hands, soles of the feet, forehead, and axillae or udnerarms
Sudoriferous Glands
Entire skin surface ecept nipples and part of external genitalia
Sweat glands
The average person loose how much fluid each day due to sweat
1/2 liter of fluid (through sweat)
Types of sweat glands
Eccrine or merocrine
Apocrine
Modified apocrine
Most numerous
Open through pores
Eccrine or merocrine
Axillary, anal, and genital areas only
Ducts open into hair follicles
Apocrine
Examples of modified apocrine glands
Ceruminous - secrete earwax
Mammary glands
Dermal Structures:
Nerves
Meissner's corpuscles Merkel's disks Pacinian corpuscles Ruffini's corpuscles Bare nerve endings
Light touch
Meissner’s corpuscles
Merkel’s disks
Deep pressure
Pacinian corpuscles
Deep pressure and stretch
Ruffini’s corpuscles
Pain, heat, and cold
Bare nerve endings
Disorders of the integumentary system
Burns
Infections
Skin cancer
Catastrophic loss of body fluids
Fatal circulatory shock
Infection
Burns
Types of burns
First degree
Second degree
Third degree
Epidermis
Redness (e.g. sunburn)
First degree
Epidermis and upper dermis
Blister
Second degree
Full thickness
Third degree
Over 10% of the body has third degree burns
25% of the body has second degree burns
Third degree burns on face, hands, or feet
Critical burns
Tumors of the skin
Benign
Cancer
Associated with UV exposure
Skin Cancer
Examples of skin cancer
Aktinic keratosis
Basal cell
Squamous cell
Melanoma
Premalignant
Aktinic keratosis
Cells of stratum basale
Basal cell
Keratinocytes
Squamous cell
Melanocytes
Most dangerous
Melanoma
Recognition of melanoma:
Assymetry
Border irregularity
Colors
Diameter larger than 6mm